Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein

Michael J. Oglesbee, Anne V. Herdman, Gregory G Passmore, William H. Hoffman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objectives: Diabetic ketoacidosis (DKA) represents a metabolic stress whose treatment induces a systemic proinflammatory cytokine profile and accentuates life-threatening acute complications. The present study determined whether serum levels of the major inducible 70-kDa heat shock protein (Hsp72), a modulator of cytokine expression, were influenced by DKA and its treatment. Design and methods: Serum levels of Hsp72 and glucose were measured in five adolescents with type 1 diabetes mellitus (T1DM) prior to, during and following correction of severe DKA. Samples from nine relatively euglycemic T1DM patients served as controls. Results: DKA pre-treatment samples showed significant elevation in Hsp72 (40.8 ± 6.9 ng/ml) relative to euglycemic T1DM controls (33.6 ± 3.2 ng/ml) (P < 0.05). Treatment resulted in a decline in Hsp72 to control levels within 24 h, with Hsp72 and glucose levels being tightly correlated (r = 0.9258). Conclusion: Extracellular Hsp72 is increased by DKA, paralleling changes in serum glucose levels.

Original languageEnglish (US)
Pages (from-to)900-904
Number of pages5
JournalClinical Biochemistry
Volume38
Issue number10
DOIs
StatePublished - Oct 1 2005

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Diabetic Ketoacidosis
HSP70 Heat-Shock Proteins
Medical problems
Glucose
Type 1 Diabetes Mellitus
Cytokines
Level control
Modulators
Serum
Physiological Stress
Therapeutics

Keywords

  • Blood glucose
  • Diabetic ketoacidosis
  • Hsp72 protein

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein. / Oglesbee, Michael J.; Herdman, Anne V.; Passmore, Gregory G; Hoffman, William H.

In: Clinical Biochemistry, Vol. 38, No. 10, 01.10.2005, p. 900-904.

Research output: Contribution to journalArticle

Oglesbee, Michael J. ; Herdman, Anne V. ; Passmore, Gregory G ; Hoffman, William H. / Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein. In: Clinical Biochemistry. 2005 ; Vol. 38, No. 10. pp. 900-904.
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