TY - JOUR
T1 - Diagnosis and Management of Acute HIV Infection
AU - Zetola, Nicola M.
AU - Pilcher, Christopher D.
N1 - Funding Information:
This paper was supported in part by the Universitywide AIDS Research Program (UARP), the San Francisco Department of Public Health, and the National Institutes of Health/National Institute of Mental Health (R01-MH068686).
PY - 2007/3
Y1 - 2007/3
N2 - HIV infection starts as an acute, systemic infection, followed by a chronic period of clinical latency, usually lasting 3 to 10 years, which precedes the eventual collapse of the immune system. It is increasingly recognized that events occurring during acute HIV infection may determine the natural course of the disease. The very dynamic events of acute HIV infection provide multiple opportunities for biologic interventions, such as anti-retroviral or immune-based therapies. Similarly, the implementation of public health measures during acute HIV infection could help control epidemics or outbreaks. Many of the dramatic possibilities for intervention in acute HIV infection remain unproved, not the least because of traditional difficulty of diagnosing patients during this early period. This article reviews the natural history, pathogenesis and clinical presentation of acute HIV infection, and suggests a diagnostic and therapeutic approach to guide clinicians dealing with patients with suspected or confirmed acute HIV infection.
AB - HIV infection starts as an acute, systemic infection, followed by a chronic period of clinical latency, usually lasting 3 to 10 years, which precedes the eventual collapse of the immune system. It is increasingly recognized that events occurring during acute HIV infection may determine the natural course of the disease. The very dynamic events of acute HIV infection provide multiple opportunities for biologic interventions, such as anti-retroviral or immune-based therapies. Similarly, the implementation of public health measures during acute HIV infection could help control epidemics or outbreaks. Many of the dramatic possibilities for intervention in acute HIV infection remain unproved, not the least because of traditional difficulty of diagnosing patients during this early period. This article reviews the natural history, pathogenesis and clinical presentation of acute HIV infection, and suggests a diagnostic and therapeutic approach to guide clinicians dealing with patients with suspected or confirmed acute HIV infection.
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U2 - 10.1016/j.idc.2007.01.008
DO - 10.1016/j.idc.2007.01.008
M3 - Review article
C2 - 17502228
AN - SCOPUS:34248351488
SN - 0891-5520
VL - 21
SP - 19
EP - 48
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
IS - 1
ER -