Diagnosis and management of Crohn's disease

Jeff T Wilkins, Kathryn Jarvis, Jigneshkumar Patel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract at any point from the mouth to the rectum. Patients may experience diarrhea, abdominal pain, fever, weight loss, abdominal masses, and anemia. Extraintestinal manifestations of Crohn's disease include osteoporosis, inflammatory arthropathies, scleritis, nephrolithiasis, cholelithiasis, and erythema nodosum. Acute phase reactants, such as C-reactive protein level and erythrocyte sedimentation rate, are often increased with inflammation and may correlate with disease activity. Levels of vitamin B12, folate, albumin, prealbumin, and vitamin D can help assess nutritional status. Colonoscopy with ileoscopy, capsule endoscopy, computed tomography enterography, and small bowel follow-through are often used to diagnose Crohn's disease. Ultrasonography, computed axial tomography, scintigraphy, and magnetic resonance imaging can assess for extraintestinal manifestations or complications (e.g., abscess, perforation). Mesalamine products are often used for the medical management of mild to moderate colonic Crohn's disease. Antibiotics (e.g., metronidazole, fluoroquinolones) are often used for treatment. Patients with moderate to severe Crohn's disease are treated with corticosteroids, azathioprine, 6-mercaptopurine, or anti-tumor necrosis factor agents (e.g., infliximab, adalimumab). Severe disease may require emergent hospitalization and a multidisciplinary approach with a family physician, gastroenterologist, and surgeon.

Original languageEnglish (US)
Pages (from-to)1365-1375
Number of pages11
JournalAmerican Family Physician
Volume84
Issue number12
StatePublished - Jan 1 2011

Fingerprint

Crohn Disease
Tomography
Scleritis
Colonic Diseases
Capsule Endoscopy
Erythema Nodosum
Mesalamine
Nephrolithiasis
6-Mercaptopurine
Prealbumin
Cholelithiasis
Acute-Phase Proteins
Joint Diseases
Blood Sedimentation
Fluoroquinolones
Metronidazole
Family Physicians
Azathioprine
Colonoscopy
Vitamin B 12

ASJC Scopus subject areas

  • Family Practice

Cite this

Wilkins, J. T., Jarvis, K., & Patel, J. (2011). Diagnosis and management of Crohn's disease. American Family Physician, 84(12), 1365-1375.

Diagnosis and management of Crohn's disease. / Wilkins, Jeff T; Jarvis, Kathryn; Patel, Jigneshkumar.

In: American Family Physician, Vol. 84, No. 12, 01.01.2011, p. 1365-1375.

Research output: Contribution to journalArticle

Wilkins, JT, Jarvis, K & Patel, J 2011, 'Diagnosis and management of Crohn's disease', American Family Physician, vol. 84, no. 12, pp. 1365-1375.
Wilkins JT, Jarvis K, Patel J. Diagnosis and management of Crohn's disease. American Family Physician. 2011 Jan 1;84(12):1365-1375.
Wilkins, Jeff T ; Jarvis, Kathryn ; Patel, Jigneshkumar. / Diagnosis and management of Crohn's disease. In: American Family Physician. 2011 ; Vol. 84, No. 12. pp. 1365-1375.
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