Diagnosis of pheochromocytoma in the setting of Parkinson disease

Shyamal H. Mehta, Rajan Prakash, L. Michael Prisant, Carlos M Isales, John Christopher Morgan, Hadyn T Williams, Kapil Dev Sethi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. A 59-year-old man with a 7-year history of Parkinson disease (PD) presented with episodes of sudden, severe headaches with neck pain, tachycardia, sweating and pallor. During these episodes, the patient showed marked elevations in blood pressure, regardless of posture. This was unusual, given that he had no prior history of hypertension. The array of symptoms raised suspicions of pheochromocytoma, but diagnosis was challenging, as the standard diagnostic biochemical tests were confounded by dopaminergic medications. Further work-up revealed left adrenal medullary hyperplasia. Several reports exist of pseudopheochromocytoma in patients on dopaminergic therapy, but this is the first documented case of pheochromocytoma syndrome due to adrenal medullary hyperplasia in a patient with PD. This case highlights the challenges of performing a diagnostic work-up in a PD patient with symptoms suggestive of pheochromocytoma, and illustrates the utility of 123I-metaiodobenzylguanidine (123I-MIBG) single-photon emission CT in making a diagnosis. Investigations. Physical examination, laboratory tests, abdominal MRI scan, abdominal 123I-MIBG scan, abdominal 18F-fluorodeoxyglucose PET scan. Diagnosis. Pheochromocytoma syndrome due to adrenal medullary hyperplasia. Management. Surgical excision of the left adrenal gland.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalNature Reviews Neurology
Volume5
Issue number6
DOIs
StatePublished - Oct 23 2009

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Pheochromocytoma
Parkinson Disease
Hyperplasia
Pallor
Sweating
Neck Pain
Fluorodeoxyglucose F18
Adrenal Glands
Posture
Photons
Routine Diagnostic Tests
Tachycardia
Positron-Emission Tomography
Physical Examination
Headache
Magnetic Resonance Imaging
Blood Pressure
Hypertension
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Diagnosis of pheochromocytoma in the setting of Parkinson disease. / Mehta, Shyamal H.; Prakash, Rajan; Prisant, L. Michael; Isales, Carlos M; Morgan, John Christopher; Williams, Hadyn T; Sethi, Kapil Dev.

In: Nature Reviews Neurology, Vol. 5, No. 6, 23.10.2009, p. 343-347.

Research output: Contribution to journalArticle

Mehta, Shyamal H. ; Prakash, Rajan ; Prisant, L. Michael ; Isales, Carlos M ; Morgan, John Christopher ; Williams, Hadyn T ; Sethi, Kapil Dev. / Diagnosis of pheochromocytoma in the setting of Parkinson disease. In: Nature Reviews Neurology. 2009 ; Vol. 5, No. 6. pp. 343-347.
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