### Abstract

The authors used logistic regression, dichotomous and multiple level likelihood ratios, and receiver operating characteristic (ROC) analyses to examine Wada Memory Asymmetries (WMAs) in 324 patients who subsequently underwent temporal lobe (TL) surgery (left TL surgery = 172; right TL surgery = 152) using the Medical College of Georgia Wada protocol. Logistic regression correctly classified 84% of left TL patients and 77% of right TL patients using WMA. Corresponding dichotomous likelihood ratios (LRs) were: LR+ = 3.64; LR- = 0.21. The area under the curve using ROC was similarly highly significant (.886, standard error = .018, p < .001). When classifying patients using multiple level LRs, 40 left TL patients (23.3%) obtained asymmetry scores greater than +4, whereas no right TL patients obtained asymmetry scores in this range. No left TL patients obtained a WMA of -8 or less, although 12 right TL patients (7.9%) obtained a difference score of -8. Multiple level LRs indicate impressive diagnostic sensitivity for certain WMA ranges, greatly increasing the probability of undergoing either left or right TL surgery depending on WMA magnitude.

Original language | English (US) |
---|---|

Pages (from-to) | 687-693 |

Number of pages | 7 |

Journal | Neuropsychology |

Volume | 23 |

Issue number | 6 |

DOIs | |

State | Published - Nov 1 2009 |

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### ASJC Scopus subject areas

- Neuropsychology and Physiological Psychology

### Cite this

*Neuropsychology*,

*23*(6), 687-693. https://doi.org/10.1037/a0016528

**Diagnostic Utility of Wada Memory Asymmetries : Sensitivity, Specificity, and Likelihood Ratio Characterization.** / Loring, David W.; Bowden, Stephen C.; Lee, Gregory P.; Meador, Kimford J.

Research output: Contribution to journal › Article

*Neuropsychology*, vol. 23, no. 6, pp. 687-693. https://doi.org/10.1037/a0016528

}

TY - JOUR

T1 - Diagnostic Utility of Wada Memory Asymmetries

T2 - Sensitivity, Specificity, and Likelihood Ratio Characterization

AU - Loring, David W.

AU - Bowden, Stephen C.

AU - Lee, Gregory P.

AU - Meador, Kimford J.

PY - 2009/11/1

Y1 - 2009/11/1

N2 - The authors used logistic regression, dichotomous and multiple level likelihood ratios, and receiver operating characteristic (ROC) analyses to examine Wada Memory Asymmetries (WMAs) in 324 patients who subsequently underwent temporal lobe (TL) surgery (left TL surgery = 172; right TL surgery = 152) using the Medical College of Georgia Wada protocol. Logistic regression correctly classified 84% of left TL patients and 77% of right TL patients using WMA. Corresponding dichotomous likelihood ratios (LRs) were: LR+ = 3.64; LR- = 0.21. The area under the curve using ROC was similarly highly significant (.886, standard error = .018, p < .001). When classifying patients using multiple level LRs, 40 left TL patients (23.3%) obtained asymmetry scores greater than +4, whereas no right TL patients obtained asymmetry scores in this range. No left TL patients obtained a WMA of -8 or less, although 12 right TL patients (7.9%) obtained a difference score of -8. Multiple level LRs indicate impressive diagnostic sensitivity for certain WMA ranges, greatly increasing the probability of undergoing either left or right TL surgery depending on WMA magnitude.

AB - The authors used logistic regression, dichotomous and multiple level likelihood ratios, and receiver operating characteristic (ROC) analyses to examine Wada Memory Asymmetries (WMAs) in 324 patients who subsequently underwent temporal lobe (TL) surgery (left TL surgery = 172; right TL surgery = 152) using the Medical College of Georgia Wada protocol. Logistic regression correctly classified 84% of left TL patients and 77% of right TL patients using WMA. Corresponding dichotomous likelihood ratios (LRs) were: LR+ = 3.64; LR- = 0.21. The area under the curve using ROC was similarly highly significant (.886, standard error = .018, p < .001). When classifying patients using multiple level LRs, 40 left TL patients (23.3%) obtained asymmetry scores greater than +4, whereas no right TL patients obtained asymmetry scores in this range. No left TL patients obtained a WMA of -8 or less, although 12 right TL patients (7.9%) obtained a difference score of -8. Multiple level LRs indicate impressive diagnostic sensitivity for certain WMA ranges, greatly increasing the probability of undergoing either left or right TL surgery depending on WMA magnitude.

UR - http://www.scopus.com/inward/record.url?scp=72149110326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72149110326&partnerID=8YFLogxK

U2 - 10.1037/a0016528

DO - 10.1037/a0016528

M3 - Article

C2 - 19899827

AN - SCOPUS:72149110326

VL - 23

SP - 687

EP - 693

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 6

ER -