Diaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary disease

M. Jeffery Mador, Thomas J. Kufel, Lilibeth A. Pineda, Gyanendra Kumar Sharma

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Patients with chronic obstructive pulmonary disease (COPD) are at a mechanical disadvantage and should be predisposed to the development of diaphragmatic fatigue when the ventilatory system is stressed by exercise. The purpose of this study was to determine whether patients with moderately severe COPD develop contractile fatigue of the diaphragm after cycle exercise to the limits of tolerance. Twelve male patients with COPD, age 61.4 ± 3.0 yr, participated. Their forced expiratory volume in 1 s (FEV1) was 1.79 ± 0.14 L, 49.6 ± 3.4% of predicted. Patients cycled at 60-70% of their predetermined maximal work capacity until they had to stop because of intolerable symptoms. Twitch transdiaphragmatic pressure (Pdi,tw) was measured during cervical magnetic stimulation before and 10, 30, and 60 min after exercise. A persistent fall in Pdi,tw postexercise of ≥ 10% was considered potentially indicative of contractile fatigue of the diaphragm. Patients cycled for 10.2 ± 2.0 min at a workload of 59.9 ± 4.3 W. Patients exercised maximally relative to their capacity reaching a peak oxygen consumption (V̇O2) of 108.1 ± 2.8% of the peak V̇O2 obtained during a preliminary maximal incremental exercise test. Pdi,tw was not significantly different from baseline at any time postexercise. Pdi,tw was 19.9 ± 1.6 cm H2O at baseline, 19.6 ± 2.0 cm H2O at 10 min postexercise, 18.6 ± 2.0 cm H2O at 30 min postexercise, and 19.5 ± 1.7 cm H2O at 60 min postexercise. In the individual patients, two of the patients had a persistent ≥ 10% fall in Pdi,tw postexercise, potentially indicative of contractile fatigue of the diaphragm. In conclusion, the majority of patients with moderately severe COPD do not develop contractile fatigue of the diaphragm after high-intensity constant workload cycle exercise to the limits of tolerance.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume161
Issue number1
StatePublished - Jan 31 2000

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Chronic Obstructive Pulmonary Disease
Fatigue
Exercise
Diaphragm
Workload
Forced Expiratory Volume
Exercise Test
Oxygen Consumption
Pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Diaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary disease. / Mador, M. Jeffery; Kufel, Thomas J.; Pineda, Lilibeth A.; Sharma, Gyanendra Kumar.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 161, No. 1, 31.01.2000, p. 118-123.

Research output: Contribution to journalArticle

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abstract = "Patients with chronic obstructive pulmonary disease (COPD) are at a mechanical disadvantage and should be predisposed to the development of diaphragmatic fatigue when the ventilatory system is stressed by exercise. The purpose of this study was to determine whether patients with moderately severe COPD develop contractile fatigue of the diaphragm after cycle exercise to the limits of tolerance. Twelve male patients with COPD, age 61.4 ± 3.0 yr, participated. Their forced expiratory volume in 1 s (FEV1) was 1.79 ± 0.14 L, 49.6 ± 3.4{\%} of predicted. Patients cycled at 60-70{\%} of their predetermined maximal work capacity until they had to stop because of intolerable symptoms. Twitch transdiaphragmatic pressure (Pdi,tw) was measured during cervical magnetic stimulation before and 10, 30, and 60 min after exercise. A persistent fall in Pdi,tw postexercise of ≥ 10{\%} was considered potentially indicative of contractile fatigue of the diaphragm. Patients cycled for 10.2 ± 2.0 min at a workload of 59.9 ± 4.3 W. Patients exercised maximally relative to their capacity reaching a peak oxygen consumption (V̇O2) of 108.1 ± 2.8{\%} of the peak V̇O2 obtained during a preliminary maximal incremental exercise test. Pdi,tw was not significantly different from baseline at any time postexercise. Pdi,tw was 19.9 ± 1.6 cm H2O at baseline, 19.6 ± 2.0 cm H2O at 10 min postexercise, 18.6 ± 2.0 cm H2O at 30 min postexercise, and 19.5 ± 1.7 cm H2O at 60 min postexercise. In the individual patients, two of the patients had a persistent ≥ 10{\%} fall in Pdi,tw postexercise, potentially indicative of contractile fatigue of the diaphragm. In conclusion, the majority of patients with moderately severe COPD do not develop contractile fatigue of the diaphragm after high-intensity constant workload cycle exercise to the limits of tolerance.",
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