Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

Alexis M. Stranahan, Eric D. Norman, Kim Lee, Roy G. Cutler, Richard S. Telljohann, Josephine M. Egan, Mark P. Mattson

Research output: Contribution to journalArticle

423 Citations (Scopus)

Abstract

Overall dietary energy intake, particularly the consumption of simple sugars such as fructose, has been increasing steadily in Western societies, but the effects of such diets on the brain are poorly understood. Here, we used functional and structural assays to characterize the effects of excessive caloric intake on the hippocampus, a brain region important for learning and memory. Rats fed with a high-fat, high-glucose diet supplemented with high-fructose corn syrup showed alterations in energy and lipid metabolism similar to clinical diabetes, with elevated fasting glucose and increased cholesterol and triglycerides. Rats maintained on this diet for 8 months exhibited impaired spatial learning ability, reduced hippocampal dendritic spine density, and reduced long-term potentiation at Schaffer collateral - CA1 synapses. These changes occurred concurrently with reductions in levels of brain-derived neurotrophic factor in the hippocampus. We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines.

Original languageEnglish (US)
Pages (from-to)1085-1088
Number of pages4
JournalHippocampus
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Neuronal Plasticity
Cognition
Insulin Resistance
Hippocampus
Dendritic Spines
Brain-Derived Neurotrophic Factor
Diet
Energy Intake
Glucose
Long-Term Potentiation
Brain
High Fat Diet
Fructose
Lipid Metabolism
Synapses
Energy Metabolism
Fasting
Triglycerides
Cholesterol
Learning

Keywords

  • BDNF
  • Diabetes
  • High-fat diet
  • Hippocampus
  • Obesity

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Stranahan, A. M., Norman, E. D., Lee, K., Cutler, R. G., Telljohann, R. S., Egan, J. M., & Mattson, M. P. (2008). Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus, 18(11), 1085-1088. https://doi.org/10.1002/hipo.20470

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. / Stranahan, Alexis M.; Norman, Eric D.; Lee, Kim; Cutler, Roy G.; Telljohann, Richard S.; Egan, Josephine M.; Mattson, Mark P.

In: Hippocampus, Vol. 18, No. 11, 01.11.2008, p. 1085-1088.

Research output: Contribution to journalArticle

Stranahan, AM, Norman, ED, Lee, K, Cutler, RG, Telljohann, RS, Egan, JM & Mattson, MP 2008, 'Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats', Hippocampus, vol. 18, no. 11, pp. 1085-1088. https://doi.org/10.1002/hipo.20470
Stranahan, Alexis M. ; Norman, Eric D. ; Lee, Kim ; Cutler, Roy G. ; Telljohann, Richard S. ; Egan, Josephine M. ; Mattson, Mark P. / Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. In: Hippocampus. 2008 ; Vol. 18, No. 11. pp. 1085-1088.
@article{5f108dc8694b4e75aee2c1680456ac33,
title = "Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats",
abstract = "Overall dietary energy intake, particularly the consumption of simple sugars such as fructose, has been increasing steadily in Western societies, but the effects of such diets on the brain are poorly understood. Here, we used functional and structural assays to characterize the effects of excessive caloric intake on the hippocampus, a brain region important for learning and memory. Rats fed with a high-fat, high-glucose diet supplemented with high-fructose corn syrup showed alterations in energy and lipid metabolism similar to clinical diabetes, with elevated fasting glucose and increased cholesterol and triglycerides. Rats maintained on this diet for 8 months exhibited impaired spatial learning ability, reduced hippocampal dendritic spine density, and reduced long-term potentiation at Schaffer collateral - CA1 synapses. These changes occurred concurrently with reductions in levels of brain-derived neurotrophic factor in the hippocampus. We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines.",
keywords = "BDNF, Diabetes, High-fat diet, Hippocampus, Obesity",
author = "Stranahan, {Alexis M.} and Norman, {Eric D.} and Kim Lee and Cutler, {Roy G.} and Telljohann, {Richard S.} and Egan, {Josephine M.} and Mattson, {Mark P.}",
year = "2008",
month = "11",
day = "1",
doi = "10.1002/hipo.20470",
language = "English (US)",
volume = "18",
pages = "1085--1088",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",
number = "11",

}

TY - JOUR

T1 - Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

AU - Stranahan, Alexis M.

AU - Norman, Eric D.

AU - Lee, Kim

AU - Cutler, Roy G.

AU - Telljohann, Richard S.

AU - Egan, Josephine M.

AU - Mattson, Mark P.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Overall dietary energy intake, particularly the consumption of simple sugars such as fructose, has been increasing steadily in Western societies, but the effects of such diets on the brain are poorly understood. Here, we used functional and structural assays to characterize the effects of excessive caloric intake on the hippocampus, a brain region important for learning and memory. Rats fed with a high-fat, high-glucose diet supplemented with high-fructose corn syrup showed alterations in energy and lipid metabolism similar to clinical diabetes, with elevated fasting glucose and increased cholesterol and triglycerides. Rats maintained on this diet for 8 months exhibited impaired spatial learning ability, reduced hippocampal dendritic spine density, and reduced long-term potentiation at Schaffer collateral - CA1 synapses. These changes occurred concurrently with reductions in levels of brain-derived neurotrophic factor in the hippocampus. We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines.

AB - Overall dietary energy intake, particularly the consumption of simple sugars such as fructose, has been increasing steadily in Western societies, but the effects of such diets on the brain are poorly understood. Here, we used functional and structural assays to characterize the effects of excessive caloric intake on the hippocampus, a brain region important for learning and memory. Rats fed with a high-fat, high-glucose diet supplemented with high-fructose corn syrup showed alterations in energy and lipid metabolism similar to clinical diabetes, with elevated fasting glucose and increased cholesterol and triglycerides. Rats maintained on this diet for 8 months exhibited impaired spatial learning ability, reduced hippocampal dendritic spine density, and reduced long-term potentiation at Schaffer collateral - CA1 synapses. These changes occurred concurrently with reductions in levels of brain-derived neurotrophic factor in the hippocampus. We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines.

KW - BDNF

KW - Diabetes

KW - High-fat diet

KW - Hippocampus

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=55549139200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55549139200&partnerID=8YFLogxK

U2 - 10.1002/hipo.20470

DO - 10.1002/hipo.20470

M3 - Article

C2 - 18651634

AN - SCOPUS:55549139200

VL - 18

SP - 1085

EP - 1088

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

IS - 11

ER -