Abstract
It has been suggested that fish oil (FO) prevents weight loss caused by physiological stress such as cancer, injury, or cardiovascular disorders. Previously, we observed that a high-fat diet containing corn and coconut oil exaggerated weight loss caused by the mixed physiological and psychological stress of repeated restraint (RR). This experiment tested the effects of a high-fat diet containing FO as the predominant lipid source in rats exposed to the mixed physiological and psychological stress of either RR or sleep deprivation (SD). FO did not prevent stress-induced hypophagia or weight loss in RR or SD rats but exaggerated the negative effects of stress on body weight in SD rats by promoting loss of lean body mass. RR caused a reduction in body fat content irrespective of dietary treatment. In SD rats, both stress and FO independently reduced body fat mass. FO did not have any effect on adrenal and thymus weights during RR or SD and did not influence corticosterone levels after 1 h of RR or after 48 or 96 h of SD. In conclusion, our results suggest that high levels of dietary FO do not improve the response to stress in rats exposed to mixed stressors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 759-765 |
| Number of pages | 7 |
| Journal | Physiology and Behavior |
| Volume | 78 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Jan 1 2003 |
| Externally published | Yes |
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Keywords
- Fish oil
- Restraint
- Sleep deprivation
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience
Cite this
Dietary fish oil does not protect rats exposed to restraint or sleep deprivation stress. / Papakonstantinou, Emilia; Ryan, Donna H.; Harris, Ruth Babette.
In: Physiology and Behavior, Vol. 78, No. 4-5, 01.01.2003, p. 759-765.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary fish oil does not protect rats exposed to restraint or sleep deprivation stress
AU - Papakonstantinou, Emilia
AU - Ryan, Donna H.
AU - Harris, Ruth Babette
PY - 2003/1/1
Y1 - 2003/1/1
N2 - It has been suggested that fish oil (FO) prevents weight loss caused by physiological stress such as cancer, injury, or cardiovascular disorders. Previously, we observed that a high-fat diet containing corn and coconut oil exaggerated weight loss caused by the mixed physiological and psychological stress of repeated restraint (RR). This experiment tested the effects of a high-fat diet containing FO as the predominant lipid source in rats exposed to the mixed physiological and psychological stress of either RR or sleep deprivation (SD). FO did not prevent stress-induced hypophagia or weight loss in RR or SD rats but exaggerated the negative effects of stress on body weight in SD rats by promoting loss of lean body mass. RR caused a reduction in body fat content irrespective of dietary treatment. In SD rats, both stress and FO independently reduced body fat mass. FO did not have any effect on adrenal and thymus weights during RR or SD and did not influence corticosterone levels after 1 h of RR or after 48 or 96 h of SD. In conclusion, our results suggest that high levels of dietary FO do not improve the response to stress in rats exposed to mixed stressors.
AB - It has been suggested that fish oil (FO) prevents weight loss caused by physiological stress such as cancer, injury, or cardiovascular disorders. Previously, we observed that a high-fat diet containing corn and coconut oil exaggerated weight loss caused by the mixed physiological and psychological stress of repeated restraint (RR). This experiment tested the effects of a high-fat diet containing FO as the predominant lipid source in rats exposed to the mixed physiological and psychological stress of either RR or sleep deprivation (SD). FO did not prevent stress-induced hypophagia or weight loss in RR or SD rats but exaggerated the negative effects of stress on body weight in SD rats by promoting loss of lean body mass. RR caused a reduction in body fat content irrespective of dietary treatment. In SD rats, both stress and FO independently reduced body fat mass. FO did not have any effect on adrenal and thymus weights during RR or SD and did not influence corticosterone levels after 1 h of RR or after 48 or 96 h of SD. In conclusion, our results suggest that high levels of dietary FO do not improve the response to stress in rats exposed to mixed stressors.
KW - Fish oil
KW - Restraint
KW - Sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=0038356399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038356399&partnerID=8YFLogxK
U2 - 10.1016/S0031-9384(03)00080-5
DO - 10.1016/S0031-9384(03)00080-5
M3 - Article
VL - 78
SP - 759
EP - 765
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 4-5
ER -