Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative

Jessica L. Krok-Schoen, Theodore M. Brasky, Rebecca P. Hunt, Thomas E. Rohan, Tamara A. Baker, Wenjun Li, Laura D Carbone, Rachel H. Mackey, Linda Snetselaar, Maryam B. Lustberg, Marian L. Neuhouser

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The prevalence of arthritis in the United States is substantial and on the rise. Long-chain n-3 polyunsaturated fatty acids, which have anti-inflammatory properties, have been shown to provide therapeutic benefit to arthritis patients; however, to date few have examined these associations with arthritis risk. Objective: The study objective was to examine the associations of long-chain n-3 polyunsaturated fatty acids intake with osteoarthritis (OA) and rheumatoid arthritis (RA) risk among postmenopausal women. Design: This was a prospective cohort study. Participants: The sample for this analysis consisted of 80,551 postmenopausal women, aged 55 to 79 years and with no history of arthritis, recruited into the Women's Health Initiative Observational Study and Clinical Trials cohort between 1993 and 1998. Women completed a 120-item food frequency questionnaire at baseline. Main outcome measures: After a median follow-up of 8 years, 22,306 incident OA and 3,348 RA cases were identified. Statistical analyses performed: Adjusted Cox regression models were used to estimate hazard ratios and 95% CI for the associations between dietary LCn-3PUFA intake and OA and RA risk. Results: Individual and total long-chain n-3 polyunsaturated fatty acids (Quintile 5 vs Quintile 1: hazard ratio 1.04, 95% CI 0.99 to 1.09 for OA; hazard ratio 1.01, 95% CI 0.90 to 1.13 for RA) were not associated with OA and RA risk. Further, no associations were observed between n-6 polyunsaturated fatty acids intake and either arthritis outcome. Conclusions: This study is the first to examine associations of long-chain n-3 polyunsaturated fatty acids intake with OA risk and the largest to examine associations with RA risk. Despite their therapeutic potential, the study provides no evidence of benefit of these nutrients in relation to arthritis risk.

Original languageEnglish (US)
Pages (from-to)2057-2069
Number of pages13
JournalJournal of the Academy of Nutrition and Dietetics
Volume118
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

women's health
Omega-3 Fatty Acids
long chain fatty acids
arthritis
Women's Health
rheumatoid arthritis
osteoarthritis
omega-3 fatty acids
Arthritis
Osteoarthritis
Rheumatoid Arthritis
polyunsaturated fatty acids
Food
therapeutics
omega-6 fatty acids
food frequency questionnaires
observational studies
anti-inflammatory activity
cohort studies
Unsaturated Fatty Acids

Keywords

  • Arthritis
  • Osteoarthritis
  • Rheumatoid arthritis
  • Women's Health Initiative
  • n-3 fatty acids

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Krok-Schoen, J. L., Brasky, T. M., Hunt, R. P., Rohan, T. E., Baker, T. A., Li, W., ... Neuhouser, M. L. (2018). Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative. Journal of the Academy of Nutrition and Dietetics, 118(11), 2057-2069. https://doi.org/10.1016/j.jand.2018.04.005

Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative. / Krok-Schoen, Jessica L.; Brasky, Theodore M.; Hunt, Rebecca P.; Rohan, Thomas E.; Baker, Tamara A.; Li, Wenjun; Carbone, Laura D; Mackey, Rachel H.; Snetselaar, Linda; Lustberg, Maryam B.; Neuhouser, Marian L.

In: Journal of the Academy of Nutrition and Dietetics, Vol. 118, No. 11, 01.11.2018, p. 2057-2069.

Research output: Contribution to journalArticle

Krok-Schoen, JL, Brasky, TM, Hunt, RP, Rohan, TE, Baker, TA, Li, W, Carbone, LD, Mackey, RH, Snetselaar, L, Lustberg, MB & Neuhouser, ML 2018, 'Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative', Journal of the Academy of Nutrition and Dietetics, vol. 118, no. 11, pp. 2057-2069. https://doi.org/10.1016/j.jand.2018.04.005
Krok-Schoen, Jessica L. ; Brasky, Theodore M. ; Hunt, Rebecca P. ; Rohan, Thomas E. ; Baker, Tamara A. ; Li, Wenjun ; Carbone, Laura D ; Mackey, Rachel H. ; Snetselaar, Linda ; Lustberg, Maryam B. ; Neuhouser, Marian L. / Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative. In: Journal of the Academy of Nutrition and Dietetics. 2018 ; Vol. 118, No. 11. pp. 2057-2069.
@article{a2f05d17aa09432ebc17a665ac832479,
title = "Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative",
abstract = "Background: The prevalence of arthritis in the United States is substantial and on the rise. Long-chain n-3 polyunsaturated fatty acids, which have anti-inflammatory properties, have been shown to provide therapeutic benefit to arthritis patients; however, to date few have examined these associations with arthritis risk. Objective: The study objective was to examine the associations of long-chain n-3 polyunsaturated fatty acids intake with osteoarthritis (OA) and rheumatoid arthritis (RA) risk among postmenopausal women. Design: This was a prospective cohort study. Participants: The sample for this analysis consisted of 80,551 postmenopausal women, aged 55 to 79 years and with no history of arthritis, recruited into the Women's Health Initiative Observational Study and Clinical Trials cohort between 1993 and 1998. Women completed a 120-item food frequency questionnaire at baseline. Main outcome measures: After a median follow-up of 8 years, 22,306 incident OA and 3,348 RA cases were identified. Statistical analyses performed: Adjusted Cox regression models were used to estimate hazard ratios and 95{\%} CI for the associations between dietary LCn-3PUFA intake and OA and RA risk. Results: Individual and total long-chain n-3 polyunsaturated fatty acids (Quintile 5 vs Quintile 1: hazard ratio 1.04, 95{\%} CI 0.99 to 1.09 for OA; hazard ratio 1.01, 95{\%} CI 0.90 to 1.13 for RA) were not associated with OA and RA risk. Further, no associations were observed between n-6 polyunsaturated fatty acids intake and either arthritis outcome. Conclusions: This study is the first to examine associations of long-chain n-3 polyunsaturated fatty acids intake with OA risk and the largest to examine associations with RA risk. Despite their therapeutic potential, the study provides no evidence of benefit of these nutrients in relation to arthritis risk.",
keywords = "Arthritis, Osteoarthritis, Rheumatoid arthritis, Women's Health Initiative, n-3 fatty acids",
author = "Krok-Schoen, {Jessica L.} and Brasky, {Theodore M.} and Hunt, {Rebecca P.} and Rohan, {Thomas E.} and Baker, {Tamara A.} and Wenjun Li and Carbone, {Laura D} and Mackey, {Rachel H.} and Linda Snetselaar and Lustberg, {Maryam B.} and Neuhouser, {Marian L.}",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.jand.2018.04.005",
language = "English (US)",
volume = "118",
pages = "2057--2069",
journal = "Journal of the Academy of Nutrition and Dietetics",
issn = "2212-2672",
publisher = "Elsevier USA",
number = "11",

}

TY - JOUR

T1 - Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative

AU - Krok-Schoen, Jessica L.

AU - Brasky, Theodore M.

AU - Hunt, Rebecca P.

AU - Rohan, Thomas E.

AU - Baker, Tamara A.

AU - Li, Wenjun

AU - Carbone, Laura D

AU - Mackey, Rachel H.

AU - Snetselaar, Linda

AU - Lustberg, Maryam B.

AU - Neuhouser, Marian L.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: The prevalence of arthritis in the United States is substantial and on the rise. Long-chain n-3 polyunsaturated fatty acids, which have anti-inflammatory properties, have been shown to provide therapeutic benefit to arthritis patients; however, to date few have examined these associations with arthritis risk. Objective: The study objective was to examine the associations of long-chain n-3 polyunsaturated fatty acids intake with osteoarthritis (OA) and rheumatoid arthritis (RA) risk among postmenopausal women. Design: This was a prospective cohort study. Participants: The sample for this analysis consisted of 80,551 postmenopausal women, aged 55 to 79 years and with no history of arthritis, recruited into the Women's Health Initiative Observational Study and Clinical Trials cohort between 1993 and 1998. Women completed a 120-item food frequency questionnaire at baseline. Main outcome measures: After a median follow-up of 8 years, 22,306 incident OA and 3,348 RA cases were identified. Statistical analyses performed: Adjusted Cox regression models were used to estimate hazard ratios and 95% CI for the associations between dietary LCn-3PUFA intake and OA and RA risk. Results: Individual and total long-chain n-3 polyunsaturated fatty acids (Quintile 5 vs Quintile 1: hazard ratio 1.04, 95% CI 0.99 to 1.09 for OA; hazard ratio 1.01, 95% CI 0.90 to 1.13 for RA) were not associated with OA and RA risk. Further, no associations were observed between n-6 polyunsaturated fatty acids intake and either arthritis outcome. Conclusions: This study is the first to examine associations of long-chain n-3 polyunsaturated fatty acids intake with OA risk and the largest to examine associations with RA risk. Despite their therapeutic potential, the study provides no evidence of benefit of these nutrients in relation to arthritis risk.

AB - Background: The prevalence of arthritis in the United States is substantial and on the rise. Long-chain n-3 polyunsaturated fatty acids, which have anti-inflammatory properties, have been shown to provide therapeutic benefit to arthritis patients; however, to date few have examined these associations with arthritis risk. Objective: The study objective was to examine the associations of long-chain n-3 polyunsaturated fatty acids intake with osteoarthritis (OA) and rheumatoid arthritis (RA) risk among postmenopausal women. Design: This was a prospective cohort study. Participants: The sample for this analysis consisted of 80,551 postmenopausal women, aged 55 to 79 years and with no history of arthritis, recruited into the Women's Health Initiative Observational Study and Clinical Trials cohort between 1993 and 1998. Women completed a 120-item food frequency questionnaire at baseline. Main outcome measures: After a median follow-up of 8 years, 22,306 incident OA and 3,348 RA cases were identified. Statistical analyses performed: Adjusted Cox regression models were used to estimate hazard ratios and 95% CI for the associations between dietary LCn-3PUFA intake and OA and RA risk. Results: Individual and total long-chain n-3 polyunsaturated fatty acids (Quintile 5 vs Quintile 1: hazard ratio 1.04, 95% CI 0.99 to 1.09 for OA; hazard ratio 1.01, 95% CI 0.90 to 1.13 for RA) were not associated with OA and RA risk. Further, no associations were observed between n-6 polyunsaturated fatty acids intake and either arthritis outcome. Conclusions: This study is the first to examine associations of long-chain n-3 polyunsaturated fatty acids intake with OA risk and the largest to examine associations with RA risk. Despite their therapeutic potential, the study provides no evidence of benefit of these nutrients in relation to arthritis risk.

KW - Arthritis

KW - Osteoarthritis

KW - Rheumatoid arthritis

KW - Women's Health Initiative

KW - n-3 fatty acids

UR - http://www.scopus.com/inward/record.url?scp=85048932079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048932079&partnerID=8YFLogxK

U2 - 10.1016/j.jand.2018.04.005

DO - 10.1016/j.jand.2018.04.005

M3 - Article

C2 - 29921541

AN - SCOPUS:85048932079

VL - 118

SP - 2057

EP - 2069

JO - Journal of the Academy of Nutrition and Dietetics

JF - Journal of the Academy of Nutrition and Dietetics

SN - 2212-2672

IS - 11

ER -