Differences in allergic sensitization by self-reported race and genetic ancestry

James J. Yang, Esteban G. Burchard, Shweta Choudhry, Christine C. Johnson, Dennis Randall Ownby, David Favro, Justin Chen, Matthew Akana, Connie Ha, Pui Yan Kwok, Richard Krajenta, Suzanne L. Havstad, Christine L. Joseph, Max A. Seibold, Mark D. Shriver, L. Keoki Williams

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Abstract

Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
Volume122
Issue number4
DOIs
StatePublished - Jan 1 2008

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African Americans
Environmental Exposure
Odds Ratio
Genetic Predisposition to Disease
Allergens
Immunoglobulin E
Cohort Studies
Population

Keywords

  • IgE
  • Self-reported race
  • allergic sensitization
  • continental population group
  • race-ethnicity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Differences in allergic sensitization by self-reported race and genetic ancestry. / Yang, James J.; Burchard, Esteban G.; Choudhry, Shweta; Johnson, Christine C.; Ownby, Dennis Randall; Favro, David; Chen, Justin; Akana, Matthew; Ha, Connie; Kwok, Pui Yan; Krajenta, Richard; Havstad, Suzanne L.; Joseph, Christine L.; Seibold, Max A.; Shriver, Mark D.; Williams, L. Keoki.

In: Journal of Allergy and Clinical Immunology, Vol. 122, No. 4, 01.01.2008.

Research output: Contribution to journalArticle

Yang, JJ, Burchard, EG, Choudhry, S, Johnson, CC, Ownby, DR, Favro, D, Chen, J, Akana, M, Ha, C, Kwok, PY, Krajenta, R, Havstad, SL, Joseph, CL, Seibold, MA, Shriver, MD & Williams, LK 2008, 'Differences in allergic sensitization by self-reported race and genetic ancestry', Journal of Allergy and Clinical Immunology, vol. 122, no. 4. https://doi.org/10.1016/j.jaci.2008.07.044
Yang, James J. ; Burchard, Esteban G. ; Choudhry, Shweta ; Johnson, Christine C. ; Ownby, Dennis Randall ; Favro, David ; Chen, Justin ; Akana, Matthew ; Ha, Connie ; Kwok, Pui Yan ; Krajenta, Richard ; Havstad, Suzanne L. ; Joseph, Christine L. ; Seibold, Max A. ; Shriver, Mark D. ; Williams, L. Keoki. / Differences in allergic sensitization by self-reported race and genetic ancestry. In: Journal of Allergy and Clinical Immunology. 2008 ; Vol. 122, No. 4.
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abstract = "Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95{\%} CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95{\%} CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.",
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AU - Burchard, Esteban G.

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AU - Johnson, Christine C.

AU - Ownby, Dennis Randall

AU - Favro, David

AU - Chen, Justin

AU - Akana, Matthew

AU - Ha, Connie

AU - Kwok, Pui Yan

AU - Krajenta, Richard

AU - Havstad, Suzanne L.

AU - Joseph, Christine L.

AU - Seibold, Max A.

AU - Shriver, Mark D.

AU - Williams, L. Keoki

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N2 - Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.

AB - Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.

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