Abstract
Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.
| Original language | English (US) |
|---|---|
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 122 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2008 |
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Keywords
- IgE
- Self-reported race
- allergic sensitization
- continental population group
- race-ethnicity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Differences in allergic sensitization by self-reported race and genetic ancestry. / Yang, James J.; Burchard, Esteban G.; Choudhry, Shweta; Johnson, Christine C.; Ownby, Dennis Randall; Favro, David; Chen, Justin; Akana, Matthew; Ha, Connie; Kwok, Pui Yan; Krajenta, Richard; Havstad, Suzanne L.; Joseph, Christine L.; Seibold, Max A.; Shriver, Mark D.; Williams, L. Keoki.
In: Journal of Allergy and Clinical Immunology, Vol. 122, No. 4, 01.01.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences in allergic sensitization by self-reported race and genetic ancestry
AU - Yang, James J.
AU - Burchard, Esteban G.
AU - Choudhry, Shweta
AU - Johnson, Christine C.
AU - Ownby, Dennis Randall
AU - Favro, David
AU - Chen, Justin
AU - Akana, Matthew
AU - Ha, Connie
AU - Kwok, Pui Yan
AU - Krajenta, Richard
AU - Havstad, Suzanne L.
AU - Joseph, Christine L.
AU - Seibold, Max A.
AU - Shriver, Mark D.
AU - Williams, L. Keoki
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.
AB - Background: Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective: We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods: We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence. Results: The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31). Conclusion: Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.
KW - IgE
KW - Self-reported race
KW - allergic sensitization
KW - continental population group
KW - race-ethnicity
UR - http://www.scopus.com/inward/record.url?scp=53049087130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53049087130&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2008.07.044
DO - 10.1016/j.jaci.2008.07.044
M3 - Article
VL - 122
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 4
ER -