TY - JOUR
T1 - Differences in angiotensin (1–7) between men and women
AU - Sullivan, Jennifer C.
AU - Rodriguez-Miguelez, Paula
AU - Zimmerman, Margaret A.
AU - Harris, Ryan A.
N1 - Publisher Copyright:
© 2015 the American Physiological Society.
PY - 2015
Y1 - 2015
N2 - In experimental animal models of hypertension, angiotensin (1–7) [ANG-(1–7)] is higher in females compared with males; however, it is less clear whether the same applies to humans. Therefore, this study sought to compare circulating concentrations of ANG-(1–7) in apparently healthy men and women under normal physiological conditions. With the use of a cross-sectional experimental design, blood was collected in EDTA anticoagulant from 42 volunteers (21 men and 21 women; and age range, 19–48 yr) for analysis of plasma concentrations of ANG-(1–7) and ANG II. Blood pressure was measured and vascular endothelial function was determined (n = 25) using the brachial artery flow-mediated dilation (FMD) test. As a result, women exhibited a higher circulating concentration of ANG-(1–7) (P = 0.04) compared with men, whereas values of ANG II were similar between groups.Baseline arterial diameter, peak diameter, and shear rate were significantly greater (P < 0.02) in men compared with women. No significant differences in FMD, FMD normalized for shear, or time to peak dilation were observed between men and women. In addition, a positive correlation between ANG-(1–7) and FMD (P = 0.04) and negative association between ANG-(1–7) with ANG II (P = 0.01) were only identified in men, whereas a positive relationship between ANG-(1–7) and diastolic blood pressure (P = 0.03) was observed in women. In conclusion:, women exhibit significantly higher plasma concentrations of ANG-(1–7) compared with men. In addition, this study describes a relationship between ANG-(1–7), vascular function, and diastolic blood pressure that appears to be sex dependent.
AB - In experimental animal models of hypertension, angiotensin (1–7) [ANG-(1–7)] is higher in females compared with males; however, it is less clear whether the same applies to humans. Therefore, this study sought to compare circulating concentrations of ANG-(1–7) in apparently healthy men and women under normal physiological conditions. With the use of a cross-sectional experimental design, blood was collected in EDTA anticoagulant from 42 volunteers (21 men and 21 women; and age range, 19–48 yr) for analysis of plasma concentrations of ANG-(1–7) and ANG II. Blood pressure was measured and vascular endothelial function was determined (n = 25) using the brachial artery flow-mediated dilation (FMD) test. As a result, women exhibited a higher circulating concentration of ANG-(1–7) (P = 0.04) compared with men, whereas values of ANG II were similar between groups.Baseline arterial diameter, peak diameter, and shear rate were significantly greater (P < 0.02) in men compared with women. No significant differences in FMD, FMD normalized for shear, or time to peak dilation were observed between men and women. In addition, a positive correlation between ANG-(1–7) and FMD (P = 0.04) and negative association between ANG-(1–7) with ANG II (P = 0.01) were only identified in men, whereas a positive relationship between ANG-(1–7) and diastolic blood pressure (P = 0.03) was observed in women. In conclusion:, women exhibit significantly higher plasma concentrations of ANG-(1–7) compared with men. In addition, this study describes a relationship between ANG-(1–7), vascular function, and diastolic blood pressure that appears to be sex dependent.
KW - ANG-(1–7)
KW - Blood pressure
KW - Renin-angiotensin system
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=84929687582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929687582&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00897.2014
DO - 10.1152/ajpheart.00897.2014
M3 - Article
C2 - 25659489
AN - SCOPUS:84929687582
SN - 0363-6135
VL - 308
SP - H1171-H1176
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 9
ER -