Different behavior of the resistance vessels of the human calf and forearm during contralateral isometric exercise, mental stress, and abnormal respiratory movements

N. J. Rusch, J. T. Shepherd, R Clinton Webb, P. M. Vanhoutte

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Experiments were conducted in normal human volunteers to compare the response of the forearm and calf vessels to contralateral isometric exercise, mental stress, resisted breathing, coughing, and the Valsalva maneuver. Blood flows were measured by means of strain-gauge plethysmography, arterial blood pressure by auscultation, and heart rate by electrocardiography. Isometric exercise of one forearm (at one-third maximal voluntary contraction) for 90 seconds caused an increase in blood pressure and heart rate; the vascular resistance decreased in the resting forearm, and increased in the calf. The decrease in forearm resistance was greater with the subjects supine and attenuated with the subjects standing or reclining head-down. With arterial occlusion of the exercising forearm just prior to cessation of the handgrip, the blood pressure and the calf resistance remained elevated, while the heart rate returned to control. The forearm resistance increased during the occlusion period and remained elevated throughout it. Mental stress caused an increase in heart rate and blood pressure and a dilation of the forearm but not of the calf vessels; these changes were smaller in standing than in supine subjects. Resisted breathing and coughing caused an increase in heart rate and in forearm blood flow, but not in calf blood flow. The Valsalva maneuver was followed by decreases in blood flow to the upper and lower limbs. The different responses in forearm and calf vessels can be explained by a central component which triggers a vasodilator pathway (possibly cholinergic) which is distributed to forearm but not to calf vessels.

Original languageEnglish (US)
JournalCirculation Research
Volume48
Issue number6 II
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Dyskinesias
Forearm
Exercise
Heart Rate
Valsalva Maneuver
Blood Pressure
Respiration
Auscultation
Plethysmography
Vasodilator Agents
Vascular Resistance
Cholinergic Agents
Dilatation
Lower Extremity
Healthy Volunteers
Arterial Pressure
Electrocardiography
Head

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Different behavior of the resistance vessels of the human calf and forearm during contralateral isometric exercise, mental stress, and abnormal respiratory movements. / Rusch, N. J.; Shepherd, J. T.; Webb, R Clinton; Vanhoutte, P. M.

In: Circulation Research, Vol. 48, No. 6 II, 01.01.1981.

Research output: Contribution to journalArticle

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