TY - JOUR
T1 - Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients
AU - Miranda Galvis, Marisol
AU - Santos-Silva, Alan Roger
AU - Freitas Jardim, Juscelino
AU - Paiva Fonseca, Felipe
AU - Lopes, Marcio A.
AU - de Almeida, Oslei Paes
AU - Lópes Pinto, Clóvis A.
AU - Kaminagakura, Estela
AU - Sawazaki-Calone, Iris
AU - Speight, Paul M.
AU - Kowalski, Luiz Paulo
N1 - Publisher Copyright:
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2018/1
Y1 - 2018/1
N2 - Objectives: Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide, and the clinical and behavioral characteristics of tumors in this group are controversial, and the literature shows divergent results. Purpose: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤40 years old). Methods: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies. Results: Clinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (P=.042) and MMP-9 (P=.001) was more frequent in young patients, only C-ErbB-2 (P=.048) and SMA (P=.048) expression correlated with lower disease-free survival (DFS) in this group of patients. Conclusion: Clinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9, and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients.
AB - Objectives: Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide, and the clinical and behavioral characteristics of tumors in this group are controversial, and the literature shows divergent results. Purpose: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤40 years old). Methods: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies. Results: Clinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (P=.042) and MMP-9 (P=.001) was more frequent in young patients, only C-ErbB-2 (P=.048) and SMA (P=.048) expression correlated with lower disease-free survival (DFS) in this group of patients. Conclusion: Clinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9, and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients.
KW - cell cycle proteins
KW - clinicopathologic characteristics
KW - local invasion proteins
KW - oral squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85026781814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026781814&partnerID=8YFLogxK
U2 - 10.1111/jop.12601
DO - 10.1111/jop.12601
M3 - Article
C2 - 28626969
AN - SCOPUS:85026781814
SN - 0904-2512
VL - 47
SP - 32
EP - 39
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
IS - 1
ER -