Differential consolidation and pattern reverberations within episodic cell assemblies in the mouse hippocampus

Remus Oşan, Guifen Chen, Ruiben Feng, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

One hallmark feature of consolidation of episodic memory is that only a fraction of original information, which is usually in a more abstract form, is selected for long-term memory storage. How does the brain perform these differential memory consolidations? To investigate the neural network mechanism that governs this selective consolidation process, we use a set of distinct fearful events to study if and how hippocampal CA1 cells engage in selective memory encoding and consolidation. We show that these distinct episodes activate a unique assembly of CA1 episodic cells, or neural cliques, whose response-selectivity ranges from general-to-specific features. A series of parametric analyses further reveal that post-learning CA1 episodic pattern replays or reverberations are mostly mediated by cells exhibiting event intensity-invariant responses, not by the intensity-sensitive cells. More importantly, reactivation cross-correlations displayed by intensity-invariant cells encoding general episodic features during immediate post-learning period tend to be stronger than those displayed by invariant cells encoding specific features. These differential reactivations within the CA1 episodic cell populations can thus provide the hippocampus with a selection mechanism to consolidate preferentially more generalized knowledge for long-term memory storage.

Original languageEnglish (US)
Article numbere16507
JournalPloS one
Volume6
Issue number2
DOIs
StatePublished - Feb 28 2011

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Reverberation
hippocampus
Consolidation
Hippocampus
Data storage equipment
mice
cells
Long-Term Memory
learning
Learning
Episodic Memory
Brain
Cells
Neural networks
neural networks
brain
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Differential consolidation and pattern reverberations within episodic cell assemblies in the mouse hippocampus. / Oşan, Remus; Chen, Guifen; Feng, Ruiben; Tsien, Joseph Zhuo.

In: PloS one, Vol. 6, No. 2, e16507, 28.02.2011.

Research output: Contribution to journalArticle

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