Differential effect of quetiapine on depressive symptoms in patients with partially responsive schizophrenia

Robin A. Emsley, Peter F Buckley, A. Martin Jones, Michael R. Greenwood

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

While atypical antipsychotics appear to be effective in reducing depressive symptoms in the acute phase of schizophrenia, little is known about their efficacy in patients with ongoing symptoms. The present study assessed whether quetiapine (Seroquel®) is more effective than haloperidol in treating depressive symptoms in patients with persistent positive symptoms, and investigated whether this effect is independent, or secondary to, reductions in other symptoms such as positive, negative or extrapyramidal symptoms. Patients with schizophrenia and a history of partial refractoriness to conventional antipsychotics who had not responded to 4 weeks of fluphenazine treatment (20 mg/day) were randomized to receive either quetiapine (600 mg/day) or haloperidol (20 mg/day) for a further 8 weeks. Change in the Positive and Negative Syndrome Scale depression factor score from baseline to endpoint was calculated and path analyses were performed on data from 269 patients. Quetiapine produced a greater reduction in depressive scores than haloperidol (-1.60 versus -0.54; p = 0.006). The path analyses indicated that this was a direct effect on depressive symptoms. These findings extend the evidence for an antidepressant effect for the novel antipsychotics in schizophrenia, and suggest that this is not limited to acutely psychotic patients.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalJournal of Psychopharmacology
Volume17
Issue number2
DOIs
StatePublished - Jun 1 2003

Fingerprint

Schizophrenia
Depression
Haloperidol
Antipsychotic Agents
Fluphenazine
Antidepressive Agents
Quetiapine Fumarate
Therapeutics

Keywords

  • Clinical efficacy
  • Depression
  • Haloperidol
  • Quetiapine
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Differential effect of quetiapine on depressive symptoms in patients with partially responsive schizophrenia. / Emsley, Robin A.; Buckley, Peter F; Jones, A. Martin; Greenwood, Michael R.

In: Journal of Psychopharmacology, Vol. 17, No. 2, 01.06.2003, p. 210-215.

Research output: Contribution to journalArticle

Emsley, Robin A. ; Buckley, Peter F ; Jones, A. Martin ; Greenwood, Michael R. / Differential effect of quetiapine on depressive symptoms in patients with partially responsive schizophrenia. In: Journal of Psychopharmacology. 2003 ; Vol. 17, No. 2. pp. 210-215.
@article{2497ea7fc5e940998e879e43ef3d4c87,
title = "Differential effect of quetiapine on depressive symptoms in patients with partially responsive schizophrenia",
abstract = "While atypical antipsychotics appear to be effective in reducing depressive symptoms in the acute phase of schizophrenia, little is known about their efficacy in patients with ongoing symptoms. The present study assessed whether quetiapine (Seroquel{\circledR}) is more effective than haloperidol in treating depressive symptoms in patients with persistent positive symptoms, and investigated whether this effect is independent, or secondary to, reductions in other symptoms such as positive, negative or extrapyramidal symptoms. Patients with schizophrenia and a history of partial refractoriness to conventional antipsychotics who had not responded to 4 weeks of fluphenazine treatment (20 mg/day) were randomized to receive either quetiapine (600 mg/day) or haloperidol (20 mg/day) for a further 8 weeks. Change in the Positive and Negative Syndrome Scale depression factor score from baseline to endpoint was calculated and path analyses were performed on data from 269 patients. Quetiapine produced a greater reduction in depressive scores than haloperidol (-1.60 versus -0.54; p = 0.006). The path analyses indicated that this was a direct effect on depressive symptoms. These findings extend the evidence for an antidepressant effect for the novel antipsychotics in schizophrenia, and suggest that this is not limited to acutely psychotic patients.",
keywords = "Clinical efficacy, Depression, Haloperidol, Quetiapine, Schizophrenia",
author = "Emsley, {Robin A.} and Buckley, {Peter F} and Jones, {A. Martin} and Greenwood, {Michael R.}",
year = "2003",
month = "6",
day = "1",
doi = "10.1177/0269881103017002010",
language = "English (US)",
volume = "17",
pages = "210--215",
journal = "Journal of Psychopharmacology",
issn = "0269-8811",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Differential effect of quetiapine on depressive symptoms in patients with partially responsive schizophrenia

AU - Emsley, Robin A.

AU - Buckley, Peter F

AU - Jones, A. Martin

AU - Greenwood, Michael R.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - While atypical antipsychotics appear to be effective in reducing depressive symptoms in the acute phase of schizophrenia, little is known about their efficacy in patients with ongoing symptoms. The present study assessed whether quetiapine (Seroquel®) is more effective than haloperidol in treating depressive symptoms in patients with persistent positive symptoms, and investigated whether this effect is independent, or secondary to, reductions in other symptoms such as positive, negative or extrapyramidal symptoms. Patients with schizophrenia and a history of partial refractoriness to conventional antipsychotics who had not responded to 4 weeks of fluphenazine treatment (20 mg/day) were randomized to receive either quetiapine (600 mg/day) or haloperidol (20 mg/day) for a further 8 weeks. Change in the Positive and Negative Syndrome Scale depression factor score from baseline to endpoint was calculated and path analyses were performed on data from 269 patients. Quetiapine produced a greater reduction in depressive scores than haloperidol (-1.60 versus -0.54; p = 0.006). The path analyses indicated that this was a direct effect on depressive symptoms. These findings extend the evidence for an antidepressant effect for the novel antipsychotics in schizophrenia, and suggest that this is not limited to acutely psychotic patients.

AB - While atypical antipsychotics appear to be effective in reducing depressive symptoms in the acute phase of schizophrenia, little is known about their efficacy in patients with ongoing symptoms. The present study assessed whether quetiapine (Seroquel®) is more effective than haloperidol in treating depressive symptoms in patients with persistent positive symptoms, and investigated whether this effect is independent, or secondary to, reductions in other symptoms such as positive, negative or extrapyramidal symptoms. Patients with schizophrenia and a history of partial refractoriness to conventional antipsychotics who had not responded to 4 weeks of fluphenazine treatment (20 mg/day) were randomized to receive either quetiapine (600 mg/day) or haloperidol (20 mg/day) for a further 8 weeks. Change in the Positive and Negative Syndrome Scale depression factor score from baseline to endpoint was calculated and path analyses were performed on data from 269 patients. Quetiapine produced a greater reduction in depressive scores than haloperidol (-1.60 versus -0.54; p = 0.006). The path analyses indicated that this was a direct effect on depressive symptoms. These findings extend the evidence for an antidepressant effect for the novel antipsychotics in schizophrenia, and suggest that this is not limited to acutely psychotic patients.

KW - Clinical efficacy

KW - Depression

KW - Haloperidol

KW - Quetiapine

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0038677025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038677025&partnerID=8YFLogxK

U2 - 10.1177/0269881103017002010

DO - 10.1177/0269881103017002010

M3 - Article

C2 - 12870569

AN - SCOPUS:0038677025

VL - 17

SP - 210

EP - 215

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 2

ER -