Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity

John W. Apolzan, Ruth Babette Harris

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Obesity has been associated with increased consumption of sweetened beverages and a high-fat diet. We determined whether the composition of the dry pellet offered with liquid sucrose (LS) and lard influenced the development of obesity. We hypothesized that animals offered LS or LS and lard (choice), in addition to chow or purified low fat diet pellet (LFD; 10% fat), would gain more body fat than controls. We compared the effects of LFD vs. chow on voluntary consumption of LS and lard, serum triglyceride (TG), glucose, and body fat over 21. days. Male Sprague Dawley rats (n = 10/group) were offered chow, chow. +. LS, chow choice, LFD, LFD. +. LS, LFD choice or solid high-sucrose diet (70% sucrose). Energy intakes of rats fed chow, LFD, and high-sucrose diets were similar. Energy intake was increased by 16% in chow. +. LS, 15% in LFD. +. LS, 11% in LFD choice, and 23% in chow choice rats. Chow choice rats consumed 142% more lard than LFD choice rats. Fasting glucose increased in all choice rats compared with the chow and high-sucrose diet rats. Fasting TG increased in LFD choice rats and were ~. 75% higher than those of chow, LFD, or high-sucrose rats. Chow choice had higher carcass fat than chow, chow. +. LS, and LFD groups however LFD choice was not different from their controls. Another experiment confirmed rats consumed 158% more lard when given chow choice compared to LFD choice. The diet offered to rats with free access to LS and lard influenced the development of obesity, sucrose and lard selection, and TG.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalPhysiology and Behavior
Volume105
Issue number2
DOIs
StatePublished - Jan 18 2012

Fingerprint

Sucrose
Obesity
Diet
Triglycerides
lard
Energy Intake
Adipose Tissue
Fasting
Fats
Glucose
Fat-Restricted Diet
Beverages
High Fat Diet
Sprague Dawley Rats

Keywords

  • Body composition
  • Chow
  • Energy intake
  • Hyperphagia
  • Macronutrient self-selection
  • Purified diet

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity. / Apolzan, John W.; Harris, Ruth Babette.

In: Physiology and Behavior, Vol. 105, No. 2, 18.01.2012, p. 325-331.

Research output: Contribution to journalArticle

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abstract = "Obesity has been associated with increased consumption of sweetened beverages and a high-fat diet. We determined whether the composition of the dry pellet offered with liquid sucrose (LS) and lard influenced the development of obesity. We hypothesized that animals offered LS or LS and lard (choice), in addition to chow or purified low fat diet pellet (LFD; 10{\%} fat), would gain more body fat than controls. We compared the effects of LFD vs. chow on voluntary consumption of LS and lard, serum triglyceride (TG), glucose, and body fat over 21. days. Male Sprague Dawley rats (n = 10/group) were offered chow, chow. +. LS, chow choice, LFD, LFD. +. LS, LFD choice or solid high-sucrose diet (70{\%} sucrose). Energy intakes of rats fed chow, LFD, and high-sucrose diets were similar. Energy intake was increased by 16{\%} in chow. +. LS, 15{\%} in LFD. +. LS, 11{\%} in LFD choice, and 23{\%} in chow choice rats. Chow choice rats consumed 142{\%} more lard than LFD choice rats. Fasting glucose increased in all choice rats compared with the chow and high-sucrose diet rats. Fasting TG increased in LFD choice rats and were ~. 75{\%} higher than those of chow, LFD, or high-sucrose rats. Chow choice had higher carcass fat than chow, chow. +. LS, and LFD groups however LFD choice was not different from their controls. Another experiment confirmed rats consumed 158{\%} more lard when given chow choice compared to LFD choice. The diet offered to rats with free access to LS and lard influenced the development of obesity, sucrose and lard selection, and TG.",
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N2 - Obesity has been associated with increased consumption of sweetened beverages and a high-fat diet. We determined whether the composition of the dry pellet offered with liquid sucrose (LS) and lard influenced the development of obesity. We hypothesized that animals offered LS or LS and lard (choice), in addition to chow or purified low fat diet pellet (LFD; 10% fat), would gain more body fat than controls. We compared the effects of LFD vs. chow on voluntary consumption of LS and lard, serum triglyceride (TG), glucose, and body fat over 21. days. Male Sprague Dawley rats (n = 10/group) were offered chow, chow. +. LS, chow choice, LFD, LFD. +. LS, LFD choice or solid high-sucrose diet (70% sucrose). Energy intakes of rats fed chow, LFD, and high-sucrose diets were similar. Energy intake was increased by 16% in chow. +. LS, 15% in LFD. +. LS, 11% in LFD choice, and 23% in chow choice rats. Chow choice rats consumed 142% more lard than LFD choice rats. Fasting glucose increased in all choice rats compared with the chow and high-sucrose diet rats. Fasting TG increased in LFD choice rats and were ~. 75% higher than those of chow, LFD, or high-sucrose rats. Chow choice had higher carcass fat than chow, chow. +. LS, and LFD groups however LFD choice was not different from their controls. Another experiment confirmed rats consumed 158% more lard when given chow choice compared to LFD choice. The diet offered to rats with free access to LS and lard influenced the development of obesity, sucrose and lard selection, and TG.

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