Differential effects of exercise training in men and women with chronic heart failure

Steven J. Keteyian, Brian D. Duscha, Clinton A. Brawner, Howie J. Green, Charles R.C. Marks, Fred H. Schachat, Brian H. Annex, William E. Kraus

Research output: Contribution to journalArticle

Abstract

Background: Abnormalities of myosin heavy chain (MHC) isoforms, enzyme activity, and capillarity contribute to the exercise intolerance that is characteristic of patients with heart failure. To what extent these changes can be reversed with exercise training and whether differences exist in the responses of men and women remains uncertain. We described and compared the effects of exercise training on exercise capacity and skeletal muscle histochemistry in men and women with chronic heart failure. Methods: Fifteen patients (10 male) undergoing standard medical therapy completed a 14- to 24-week exercise training program. Peak oxygen consumption, MHC isoforms, capillary density, and selected metabolic enzymes were assessed before and after training. Results: Peak oxygen consumption was improved 14% (P <.05); however, this increase was mostly because of the improvement observed in men versus women (+20% versus +2%, respectively, P < .01). At baseline, MHC I content was lower in men than in women (33% ± 3% vs 49.6% ± 5.5%, P < .05). MHC I improved with training in men, to 45.6% ± 4.5% (+38%, P < .05), versus women (-3%, P = .82), and the increase in men tended (P = .12) to be significant when compared with that in women. There were no significant changes in capillary density or muscle enzyme activity with training in the group as a whole or in men and women separately. Conclusion: Among patients with chronic heart failure, improvements in peak exercise capacity may be more pronounced in men than in women. This difference in response of functional capacity to training paralleled differences observed between men and women for changes in MHC I isoforms.

Original languageEnglish (US)
Pages (from-to)912-918
Number of pages7
JournalAmerican Heart Journal
Volume145
Issue number5
DOIs
StatePublished - May 1 2003

Fingerprint

Heart Failure
Exercise
Myosin Heavy Chains
Protein Isoforms
Oxygen Consumption
Enzymes
Capillary Action
Teaching
Skeletal Muscle
Education
Muscles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Keteyian, S. J., Duscha, B. D., Brawner, C. A., Green, H. J., Marks, C. R. C., Schachat, F. H., ... Kraus, W. E. (2003). Differential effects of exercise training in men and women with chronic heart failure. American Heart Journal, 145(5), 912-918. https://doi.org/10.1016/S0002-8703(03)00075-9

Differential effects of exercise training in men and women with chronic heart failure. / Keteyian, Steven J.; Duscha, Brian D.; Brawner, Clinton A.; Green, Howie J.; Marks, Charles R.C.; Schachat, Fred H.; Annex, Brian H.; Kraus, William E.

In: American Heart Journal, Vol. 145, No. 5, 01.05.2003, p. 912-918.

Research output: Contribution to journalArticle

Keteyian, SJ, Duscha, BD, Brawner, CA, Green, HJ, Marks, CRC, Schachat, FH, Annex, BH & Kraus, WE 2003, 'Differential effects of exercise training in men and women with chronic heart failure', American Heart Journal, vol. 145, no. 5, pp. 912-918. https://doi.org/10.1016/S0002-8703(03)00075-9
Keteyian SJ, Duscha BD, Brawner CA, Green HJ, Marks CRC, Schachat FH et al. Differential effects of exercise training in men and women with chronic heart failure. American Heart Journal. 2003 May 1;145(5):912-918. https://doi.org/10.1016/S0002-8703(03)00075-9
Keteyian, Steven J. ; Duscha, Brian D. ; Brawner, Clinton A. ; Green, Howie J. ; Marks, Charles R.C. ; Schachat, Fred H. ; Annex, Brian H. ; Kraus, William E. / Differential effects of exercise training in men and women with chronic heart failure. In: American Heart Journal. 2003 ; Vol. 145, No. 5. pp. 912-918.
@article{e0e1abc3a9124412a5691ecd5162c8c3,
title = "Differential effects of exercise training in men and women with chronic heart failure",
abstract = "Background: Abnormalities of myosin heavy chain (MHC) isoforms, enzyme activity, and capillarity contribute to the exercise intolerance that is characteristic of patients with heart failure. To what extent these changes can be reversed with exercise training and whether differences exist in the responses of men and women remains uncertain. We described and compared the effects of exercise training on exercise capacity and skeletal muscle histochemistry in men and women with chronic heart failure. Methods: Fifteen patients (10 male) undergoing standard medical therapy completed a 14- to 24-week exercise training program. Peak oxygen consumption, MHC isoforms, capillary density, and selected metabolic enzymes were assessed before and after training. Results: Peak oxygen consumption was improved 14{\%} (P <.05); however, this increase was mostly because of the improvement observed in men versus women (+20{\%} versus +2{\%}, respectively, P < .01). At baseline, MHC I content was lower in men than in women (33{\%} ± 3{\%} vs 49.6{\%} ± 5.5{\%}, P < .05). MHC I improved with training in men, to 45.6{\%} ± 4.5{\%} (+38{\%}, P < .05), versus women (-3{\%}, P = .82), and the increase in men tended (P = .12) to be significant when compared with that in women. There were no significant changes in capillary density or muscle enzyme activity with training in the group as a whole or in men and women separately. Conclusion: Among patients with chronic heart failure, improvements in peak exercise capacity may be more pronounced in men than in women. This difference in response of functional capacity to training paralleled differences observed between men and women for changes in MHC I isoforms.",
author = "Keteyian, {Steven J.} and Duscha, {Brian D.} and Brawner, {Clinton A.} and Green, {Howie J.} and Marks, {Charles R.C.} and Schachat, {Fred H.} and Annex, {Brian H.} and Kraus, {William E.}",
year = "2003",
month = "5",
day = "1",
doi = "10.1016/S0002-8703(03)00075-9",
language = "English (US)",
volume = "145",
pages = "912--918",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Differential effects of exercise training in men and women with chronic heart failure

AU - Keteyian, Steven J.

AU - Duscha, Brian D.

AU - Brawner, Clinton A.

AU - Green, Howie J.

AU - Marks, Charles R.C.

AU - Schachat, Fred H.

AU - Annex, Brian H.

AU - Kraus, William E.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background: Abnormalities of myosin heavy chain (MHC) isoforms, enzyme activity, and capillarity contribute to the exercise intolerance that is characteristic of patients with heart failure. To what extent these changes can be reversed with exercise training and whether differences exist in the responses of men and women remains uncertain. We described and compared the effects of exercise training on exercise capacity and skeletal muscle histochemistry in men and women with chronic heart failure. Methods: Fifteen patients (10 male) undergoing standard medical therapy completed a 14- to 24-week exercise training program. Peak oxygen consumption, MHC isoforms, capillary density, and selected metabolic enzymes were assessed before and after training. Results: Peak oxygen consumption was improved 14% (P <.05); however, this increase was mostly because of the improvement observed in men versus women (+20% versus +2%, respectively, P < .01). At baseline, MHC I content was lower in men than in women (33% ± 3% vs 49.6% ± 5.5%, P < .05). MHC I improved with training in men, to 45.6% ± 4.5% (+38%, P < .05), versus women (-3%, P = .82), and the increase in men tended (P = .12) to be significant when compared with that in women. There were no significant changes in capillary density or muscle enzyme activity with training in the group as a whole or in men and women separately. Conclusion: Among patients with chronic heart failure, improvements in peak exercise capacity may be more pronounced in men than in women. This difference in response of functional capacity to training paralleled differences observed between men and women for changes in MHC I isoforms.

AB - Background: Abnormalities of myosin heavy chain (MHC) isoforms, enzyme activity, and capillarity contribute to the exercise intolerance that is characteristic of patients with heart failure. To what extent these changes can be reversed with exercise training and whether differences exist in the responses of men and women remains uncertain. We described and compared the effects of exercise training on exercise capacity and skeletal muscle histochemistry in men and women with chronic heart failure. Methods: Fifteen patients (10 male) undergoing standard medical therapy completed a 14- to 24-week exercise training program. Peak oxygen consumption, MHC isoforms, capillary density, and selected metabolic enzymes were assessed before and after training. Results: Peak oxygen consumption was improved 14% (P <.05); however, this increase was mostly because of the improvement observed in men versus women (+20% versus +2%, respectively, P < .01). At baseline, MHC I content was lower in men than in women (33% ± 3% vs 49.6% ± 5.5%, P < .05). MHC I improved with training in men, to 45.6% ± 4.5% (+38%, P < .05), versus women (-3%, P = .82), and the increase in men tended (P = .12) to be significant when compared with that in women. There were no significant changes in capillary density or muscle enzyme activity with training in the group as a whole or in men and women separately. Conclusion: Among patients with chronic heart failure, improvements in peak exercise capacity may be more pronounced in men than in women. This difference in response of functional capacity to training paralleled differences observed between men and women for changes in MHC I isoforms.

UR - http://www.scopus.com/inward/record.url?scp=0038065615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038065615&partnerID=8YFLogxK

U2 - 10.1016/S0002-8703(03)00075-9

DO - 10.1016/S0002-8703(03)00075-9

M3 - Article

C2 - 12766753

AN - SCOPUS:0038065615

VL - 145

SP - 912

EP - 918

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 5

ER -