Differential effects of left versus right seizure focus on human hippocampal evoked responses

Kimford J. Meador, David W. Loring, Brian B. Gallagher, Don W. King, Anthony M Murro, Elaine E. Thompson, Gregory P Lee, Herman F. Flanigin, Joseph R. Smith, Jennifer Dushku, Harry Davis

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalInternational Journal of Neuroscience
Volume66
Issue number1-2
DOIs
StatePublished - Jan 1 1992

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Keywords

  • Epilepsy
  • Evoked potentials
  • Hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Meador, K. J., Loring, D. W., Gallagher, B. B., King, D. W., Murro, A. M., Thompson, E. E., Lee, G. P., Flanigin, H. F., Smith, J. R., Dushku, J., & Davis, H. (1992). Differential effects of left versus right seizure focus on human hippocampal evoked responses. International Journal of Neuroscience, 66(1-2), 87-91. https://doi.org/10.3109/00207459208999792