Differential impact of stress reduction programs upon ambulatory blood pressure among African American adolescents

Influences of endothelin-1 gene and chronic stress exposure

Mathew J. Gregoski, Vernon A Barnes, Martha S Tingen, Yanbin Dong, Haidong Zhu, Frank A. Treiber

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.

Original languageEnglish (US)
Article number510291
JournalInternational Journal of Hypertension
Volume2012
DOIs
StatePublished - Nov 7 2012

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Meditation
Endothelin-1
African Americans
Respiration
Blood Pressure
Single Nucleotide Polymorphism
Genes
Ambulatory Monitoring
Gene-Environment Interaction
Precision Medicine
Preventive Medicine
Health Education
Prescriptions
Databases
Delivery of Health Care

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Differential impact of stress reduction programs upon ambulatory blood pressure among African American adolescents: Influences of endothelin-1 gene and chronic stress exposure",
abstract = "Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.",
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