Differential induction of c-jun expression by PGF2-alpha in rat ovary, uterus and adrenal

I. Khan, A. Hossain, G. F. Whitman, P. G. McDonough, N. H. Sarkar

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The influence of PGF2∝ on c-jun gene expression in ovary, uterus and adrenal was examined. Three and seven day postovulatory PMSG primed immature rats received 500 μg PGF2∝ by two subcutaneous injections 8 hours apart. Control rats received saline. Animals were sacrified 30 minutes after the second injection of PGF2∝. Tissues were obtained and frozen in liquid nitrogen. RNA extracted from ovary, uterus and adrenal was analyzed by Northern and slot blot. c-jun was expressed differentially in these organs. An increase in c-jun expression by PGF2∝ treatment occurred in the ovary but not in the adrenal and uterus. The effect of PGF2∝ on c-jun was stronger in older compared to younger corpora lutea. These results indicate differential regulation of c-jun by PGF2∝ in steroidogenic and steroid responsive tissues and that c-jun might be linked to the mode of action of PGF2∝ in luteolysis.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalProstaglandins
Volume46
Issue number2
DOIs
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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    Khan, I., Hossain, A., Whitman, G. F., McDonough, P. G., & Sarkar, N. H. (1993). Differential induction of c-jun expression by PGF2-alpha in rat ovary, uterus and adrenal. Prostaglandins, 46(2), 139-144. https://doi.org/10.1016/0090-6980(93)90039-A