Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection

N. D. Jones, S. E. Turvey, A. Van Maurik, M. Hara, C. I. Kingsley, C. H. Smith, A. L. Mellor, P. J. Morris, K. J. Wood

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Abstract

Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2Kb+ skin and islet allografts to rejection is not based on their ability to activate more H-2Kb-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2Kb-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.

Original languageEnglish (US)
Pages (from-to)2824-2830
Number of pages7
JournalJournal of Immunology
Volume166
Issue number4
DOIs
StatePublished - Feb 15 2001

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Jones, N. D., Turvey, S. E., Van Maurik, A., Hara, M., Kingsley, C. I., Smith, C. H., Mellor, A. L., Morris, P. J., & Wood, K. J. (2001). Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. Journal of Immunology, 166(4), 2824-2830. https://doi.org/10.4049/jimmunol.166.4.2824