Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection

N. D. Jones, S. E. Turvey, A. Van Maurik, M. Hara, C. I. Kingsley, C. H. Smith, A. L. Mellor, P. J. Morris, K. J. Wood

Research output: Contribution to journalArticle

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Abstract

Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K b+ skin and islet allografts to rejection is not based on their ability to activate more H-2K b -specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2K b -specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.

Original languageEnglish (US)
Pages (from-to)2824-2830
Number of pages7
JournalJournal of Immunology
Volume166
Issue number4
DOIs
StatePublished - Feb 15 2001

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Allografts
T-Lymphocytes
Skin
Transplants
Graft Rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Jones, N. D., Turvey, S. E., Van Maurik, A., Hara, M., Kingsley, C. I., Smith, C. H., ... Wood, K. J. (2001). Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. Journal of Immunology, 166(4), 2824-2830. https://doi.org/10.4049/jimmunol.166.4.2824

Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. / Jones, N. D.; Turvey, S. E.; Van Maurik, A.; Hara, M.; Kingsley, C. I.; Smith, C. H.; Mellor, A. L.; Morris, P. J.; Wood, K. J.

In: Journal of Immunology, Vol. 166, No. 4, 15.02.2001, p. 2824-2830.

Research output: Contribution to journalArticle

Jones, ND, Turvey, SE, Van Maurik, A, Hara, M, Kingsley, CI, Smith, CH, Mellor, AL, Morris, PJ & Wood, KJ 2001, 'Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection', Journal of Immunology, vol. 166, no. 4, pp. 2824-2830. https://doi.org/10.4049/jimmunol.166.4.2824
Jones ND, Turvey SE, Van Maurik A, Hara M, Kingsley CI, Smith CH et al. Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. Journal of Immunology. 2001 Feb 15;166(4):2824-2830. https://doi.org/10.4049/jimmunol.166.4.2824
Jones, N. D. ; Turvey, S. E. ; Van Maurik, A. ; Hara, M. ; Kingsley, C. I. ; Smith, C. H. ; Mellor, A. L. ; Morris, P. J. ; Wood, K. J. / Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. In: Journal of Immunology. 2001 ; Vol. 166, No. 4. pp. 2824-2830.
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