Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.

Original languageEnglish (US)
Pages (from-to)748-750
Number of pages3
JournalJournal of Investigative Dermatology
Volume127
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint Dive into the research topics of 'Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators'. Together they form a unique fingerprint.

  • Cite this