Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators

Wendy B. Bollag

doi:10.1038/sj.jid.5700692

Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators

Wendy B. Bollag

Physiology

Research output: Contribution to journal › Comment/debate › peer-review

10 Scopus citations

Abstract

1,25-Dihydroxyvitamin D₃ exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.

Original language	English (US)
Pages (from-to)	748-750
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	4
DOIs	https://doi.org/10.1038/sj.jid.5700692
State	Published - Apr 2007

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

Access to Document

10.1038/sj.jid.5700692

Fingerprint Dive into the research topics of 'Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators'. Together they form a unique fingerprint.

Cite this

@article{614eb4a7be964bcca63416e8688b8772,

title = "Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators",

abstract = "1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.",

author = "Bollag, {Wendy B.}",

year = "2007",

month = apr,

doi = "10.1038/sj.jid.5700692",

language = "English (US)",

volume = "127",

pages = "748--750",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators

AU - Bollag, Wendy B.

PY - 2007/4

Y1 - 2007/4

N2 - 1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.

AB - 1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.

UR - http://www.scopus.com/inward/record.url?scp=33947220467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947220467&partnerID=8YFLogxK

U2 - 10.1038/sj.jid.5700692

DO - 10.1038/sj.jid.5700692

M3 - Comment/debate

C2 - 17363957

AN - SCOPUS:33947220467

VL - 127

SP - 748

EP - 750

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 4

ER -