TY - JOUR
T1 - Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators
AU - Bollag, Wendy B.
PY - 2007/4
Y1 - 2007/4
N2 - 1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.
AB - 1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.
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U2 - 10.1038/sj.jid.5700692
DO - 10.1038/sj.jid.5700692
M3 - Comment/debate
C2 - 17363957
AN - SCOPUS:33947220467
VL - 127
SP - 748
EP - 750
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 4
ER -