Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators

Wendy B. Bollag

doi:10.1038/sj.jid.5700692

Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators

Wendy B. Bollag

Physiology

Research output: Contribution to journal › Comment/debate

10 Scopus citations

Abstract

1,25-Dihydroxyvitamin D₃ exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.

Original language	English (US)
Pages (from-to)	748-750
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	4
DOIs	https://doi.org/10.1038/sj.jid.5700692
Publication status	Published - Apr 2007

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ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

Cite this

Bollag, W. B. (2007). Differentiation of human keratinocytes requires the vitamin D receptor and its coactivators. Journal of Investigative Dermatology, 127(4), 748-750. https://doi.org/10.1038/sj.jid.5700692

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10.1038/sj.jid.5700692