Dipeptide metabolism in the isolated perfused rat kidney

M. C. Fonteles, V. Ganapathy, D. H. Pashley, F. H. Leibach

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Renal handling of glycyl-proline was studied in the isolated perfused rat kidney. Glycyl-proline disappeared from the perfusate as a function of time. The dipeptide was freely filtered at the glomerulus but only 6% of the filtered load was excreted in the urine as the intact peptide. More than 90% of the filtered dipeptide was reabsorbed as the intact peptide and/or its hydrolytic products. Non-filtration mechanisms were also involved to a significant extent in the clearance of the peptide. Hydrolysis at intratubular, intracellular and peritubular sites all contribute to the disappearance of the dipeptide from the perfusate, though the relative contributions of each mechanism are not known. Significant metabolic conversions, especially the conversion of glycine to serine, were also observed during perfusion.

Original languageEnglish (US)
Pages (from-to)431-436,IN1-IN2
JournalLife sciences
Volume33
Issue number5
DOIs
StatePublished - Aug 1 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Fonteles, M. C., Ganapathy, V., Pashley, D. H., & Leibach, F. H. (1983). Dipeptide metabolism in the isolated perfused rat kidney. Life sciences, 33(5), 431-436,IN1-IN2. https://doi.org/10.1016/0024-3205(83)90791-9