Direct and Doppler angle-independent measurement of blood flow velocity in small-diameter vessels using ultrasound microbubbles

Homagni Sikha Roy, Guoqing Zuo, Zhengchun Luo, Hanping Wu, Tianyi M. Krupka, Haitao Ran, Pan Li, Youping Sun, Zhigang Wang, Yuanyi Zheng

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This article represents an initial attempt to demonstrate the feasibility of a novel method for measuring flow velocity in small vessels, which is a direct, noninvasive, ultrasound-guided, and Doppler angle-independent method. In vitro, experiments were designed to mimic blood flow inside tubes. Harmonic ultrasound imaging was used to track the movement of microbubbles, and the mean flow velocity was calculated. In vivo, the flow velocities were measured in the central arteries of rabbit ears. This method can be used whenever the Doppler ultrasound cannot measure the velocity in small vessels because of either low sensitivity or Doppler angle limitation.

Original languageEnglish (US)
Pages (from-to)577-583
Number of pages7
JournalClinical Imaging
Volume36
Issue number5
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • Direct
  • Doppler angle independent
  • Small vessels
  • Ultrasound microbubbles
  • Velocity measurement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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