Direct electrochemical evaluation of plasma membrane cholesterol in live mammalian cells

Dechen Jiang, Anando Devadoss, M. Simona Palencsár, Danjun Fang, Nicole M. White, Thomas J. Kelley, Jonathan D. Smith, James D. Burgess

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Cholesterol is a tightly regulated structural component of the cell plasma membrane. Dysfunctional intracellular cholesterol transport machinery causes disease states with altered plasma membrane cholesterol. This Communication reports microelectrode evaluation of plasma membrane cholesterol of single cells at physiological temperature. Electrochemical data indicate that transport of intracellular cholesterol to the plasma membrane is active in an atherosclerotic macrophage model.

Original languageEnglish (US)
Pages (from-to)11352-11353
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number37
DOIs
StatePublished - Sep 19 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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    Jiang, D., Devadoss, A., Palencsár, M. S., Fang, D., White, N. M., Kelley, T. J., Smith, J. D., & Burgess, J. D. (2007). Direct electrochemical evaluation of plasma membrane cholesterol in live mammalian cells. Journal of the American Chemical Society, 129(37), 11352-11353. https://doi.org/10.1021/ja074373c