Discordant uptake of three different agents for liver scintigraphy in a patient with focal nodular hyperplasia

Ali Syed Arbab, K. Koizumi, S. Hiraike, T. Arai, K. Mera, K. Ohtomo, T. Ainota, Y. Akahane, T. Uetake

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Focal nodular hyperplasia of the liver is composed of hepatocytes, variable amounts of Kupffer cells, and bile ducts. The amount of Kupffer cells per unit volume of tissue determines the uptake of Tc-99m phytate. However, the uptake of Tc-99m DTPA galactosyl human serum albumin (Tc-99m GSA) depends on the presence of normally functioning hepatocytes, and the uptake and excretion of Tc-99m pyridoxyledene-5-methyl tryptophen (Tc-99m PMT) depends on the presence of normally functioning hepatocytes as well as the patency of bile ducts. In this proven case of focal nodular hyperplasia, there was no uptake of Tc-99m phytate, but mildly decreased uptake of Tc-99m GSA and increased uptake of Tc-99m PMT were observed, compared to normal liver tissue. These are exceptional findings for focal nodular hyperplasia and mimicked those of a hepatic adenoma.

Original languageEnglish (US)
Pages (from-to)937-939
Number of pages3
JournalClinical Nuclear Medicine
Volume20
Issue number10
DOIs
StatePublished - Oct 20 1995
Externally publishedYes

Fingerprint

Focal Nodular Hyperplasia
Technetium Tc 99m Pentetate
Radionuclide Imaging
Hepatocytes
Kupffer Cells
Bile Ducts
Serum Albumin
Liver
Adenoma
technetium phytate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Discordant uptake of three different agents for liver scintigraphy in a patient with focal nodular hyperplasia. / Arbab, Ali Syed; Koizumi, K.; Hiraike, S.; Arai, T.; Mera, K.; Ohtomo, K.; Ainota, T.; Akahane, Y.; Uetake, T.

In: Clinical Nuclear Medicine, Vol. 20, No. 10, 20.10.1995, p. 937-939.

Research output: Contribution to journalArticle

Arbab, AS, Koizumi, K, Hiraike, S, Arai, T, Mera, K, Ohtomo, K, Ainota, T, Akahane, Y & Uetake, T 1995, 'Discordant uptake of three different agents for liver scintigraphy in a patient with focal nodular hyperplasia', Clinical Nuclear Medicine, vol. 20, no. 10, pp. 937-939. https://doi.org/10.1097/00003072-199510000-00024
Arbab, Ali Syed ; Koizumi, K. ; Hiraike, S. ; Arai, T. ; Mera, K. ; Ohtomo, K. ; Ainota, T. ; Akahane, Y. ; Uetake, T. / Discordant uptake of three different agents for liver scintigraphy in a patient with focal nodular hyperplasia. In: Clinical Nuclear Medicine. 1995 ; Vol. 20, No. 10. pp. 937-939.
@article{bfe4702ac10045ebb3bb992e8c3863ea,
title = "Discordant uptake of three different agents for liver scintigraphy in a patient with focal nodular hyperplasia",
abstract = "Focal nodular hyperplasia of the liver is composed of hepatocytes, variable amounts of Kupffer cells, and bile ducts. The amount of Kupffer cells per unit volume of tissue determines the uptake of Tc-99m phytate. However, the uptake of Tc-99m DTPA galactosyl human serum albumin (Tc-99m GSA) depends on the presence of normally functioning hepatocytes, and the uptake and excretion of Tc-99m pyridoxyledene-5-methyl tryptophen (Tc-99m PMT) depends on the presence of normally functioning hepatocytes as well as the patency of bile ducts. In this proven case of focal nodular hyperplasia, there was no uptake of Tc-99m phytate, but mildly decreased uptake of Tc-99m GSA and increased uptake of Tc-99m PMT were observed, compared to normal liver tissue. These are exceptional findings for focal nodular hyperplasia and mimicked those of a hepatic adenoma.",
author = "Arbab, {Ali Syed} and K. Koizumi and S. Hiraike and T. Arai and K. Mera and K. Ohtomo and T. Ainota and Y. Akahane and T. Uetake",
year = "1995",
month = "10",
day = "20",
doi = "10.1097/00003072-199510000-00024",
language = "English (US)",
volume = "20",
pages = "937--939",
journal = "Clinical Nuclear Medicine",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Discordant uptake of three different agents for liver scintigraphy in a patient with focal nodular hyperplasia

AU - Arbab, Ali Syed

AU - Koizumi, K.

AU - Hiraike, S.

AU - Arai, T.

AU - Mera, K.

AU - Ohtomo, K.

AU - Ainota, T.

AU - Akahane, Y.

AU - Uetake, T.

PY - 1995/10/20

Y1 - 1995/10/20

N2 - Focal nodular hyperplasia of the liver is composed of hepatocytes, variable amounts of Kupffer cells, and bile ducts. The amount of Kupffer cells per unit volume of tissue determines the uptake of Tc-99m phytate. However, the uptake of Tc-99m DTPA galactosyl human serum albumin (Tc-99m GSA) depends on the presence of normally functioning hepatocytes, and the uptake and excretion of Tc-99m pyridoxyledene-5-methyl tryptophen (Tc-99m PMT) depends on the presence of normally functioning hepatocytes as well as the patency of bile ducts. In this proven case of focal nodular hyperplasia, there was no uptake of Tc-99m phytate, but mildly decreased uptake of Tc-99m GSA and increased uptake of Tc-99m PMT were observed, compared to normal liver tissue. These are exceptional findings for focal nodular hyperplasia and mimicked those of a hepatic adenoma.

AB - Focal nodular hyperplasia of the liver is composed of hepatocytes, variable amounts of Kupffer cells, and bile ducts. The amount of Kupffer cells per unit volume of tissue determines the uptake of Tc-99m phytate. However, the uptake of Tc-99m DTPA galactosyl human serum albumin (Tc-99m GSA) depends on the presence of normally functioning hepatocytes, and the uptake and excretion of Tc-99m pyridoxyledene-5-methyl tryptophen (Tc-99m PMT) depends on the presence of normally functioning hepatocytes as well as the patency of bile ducts. In this proven case of focal nodular hyperplasia, there was no uptake of Tc-99m phytate, but mildly decreased uptake of Tc-99m GSA and increased uptake of Tc-99m PMT were observed, compared to normal liver tissue. These are exceptional findings for focal nodular hyperplasia and mimicked those of a hepatic adenoma.

UR - http://www.scopus.com/inward/record.url?scp=0029157844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029157844&partnerID=8YFLogxK

U2 - 10.1097/00003072-199510000-00024

DO - 10.1097/00003072-199510000-00024

M3 - Article

VL - 20

SP - 937

EP - 939

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 10

ER -