Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

Cecilia Arana Yi, Ghayathri Jeyakumar, Pedro Medina, Jorge Cortes, Sherry Pierce, Carlos Bueso-Ramos, Hagop Kantarjian, Srdan Verstovsek

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.

Original languageEnglish (US)
Pages (from-to)91-94
Number of pages4
JournalLeukemia Research
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Diagnostic discrepancy
  • JAKV617F mutation
  • Primary myelofibrosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Arana Yi, C., Jeyakumar, G., Medina, P., Cortes, J., Pierce, S., Bueso-Ramos, C., Kantarjian, H., & Verstovsek, S. (2014). Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers. Leukemia Research, 38(1), 91-94. https://doi.org/10.1016/j.leukres.2013.11.002