Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers

Cecilia Arana Yi, Ghayathri Jeyakumar, Pedro Medina, Jorge Cortes, Sherry Pierce, Carlos Bueso-Ramos, Hagop Kantarjian, Srdan Verstovsek

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Primary myelofibrosis (PMF) is myeloproliferative neoplasm whose diagnosis is based on a combination of clinical and pathology criteria. We evaluated 560 consecutive patients who were diagnosed with PMF upon a referral to our center and evaluated the frequency of and reasons for diagnostic discordance. Discordance in the diagnosis was found in 70 (12.5%) patients. Discordant cases had a significantly lower grade of bone marrow fibrosis (grade 0-1), more likely to be JAK2V617F-mutation negative, and have no peripheral blood blasts, possibly explaining the difficulty in making a proper diagnosis and underscoring the need for a complete evaluation at a tertiary center.

Original languageEnglish (US)
Pages (from-to)91-94
Number of pages4
JournalLeukemia Research
Volume38
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Diagnostic discrepancy
  • JAKV617F mutation
  • Primary myelofibrosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Discrepancy in diagnosis of primary myelofibrosis between referral and tertiary care centers'. Together they form a unique fingerprint.

Cite this