Disrupting basolateral amygdala function impairs unconditioned freezing and avoidance in rats

Almira Ivanova Vazdarjanova, Larry Cahill, James L. McGaugh

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Lesions of the lateral/basolateral amygdala nuclei (BLC) disrupt freezing behaviour in response to explicit or contextual cues (conditioned stimuli - CS) paired previously with footshock (unconditioned stimulus). This deficit in expression of defensive behaviour in response to conditioned stimuli is often interpreted as inability of lesioned rats to learn CS-US associations. However, findings of several studies indicate that BLC-lesioned rats can rapidly learn CS-US associations. Such findings suggest that lesioned rats can learn CS-US associations but are impaired in the expression of freezing behaviour. In the present study we report that both temporary inactivation (lidocaine) and permanent excitotoxic (NMDA) lesions of the BLC impair the unconditioned freezing and avoidance behaviours of rats in response to a novel fear-eliciting stimulus, a ball of cat hair. These findings suggest that the BLC influences the expression of freezing and avoidance behaviours, and/or that it potentiates rats' experience of fear. Along with prior evidence of spared memory for aversive learning after BLC lesions, these findings suggest that disrupted freezing to conditioned cues in BLC-lesioned rats does not necessarily reflect inability to form CS-US associations.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalEuropean Journal of Neuroscience
Volume14
Issue number4
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Freezing
Avoidance Learning
Fear
Cues
Bezoars
N-Methylaspartate
Lidocaine
Basolateral Nuclear Complex
Cats
Learning

Keywords

  • Cat hair
  • Excitotoxic lesions
  • Fear conditioning
  • Lidocaine
  • Predator odour

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Disrupting basolateral amygdala function impairs unconditioned freezing and avoidance in rats. / Vazdarjanova, Almira Ivanova; Cahill, Larry; McGaugh, James L.

In: European Journal of Neuroscience, Vol. 14, No. 4, 01.01.2002, p. 709-718.

Research output: Contribution to journalArticle

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