Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma

Donn M. Stewart, Roshan Ramanathan, Siddhartha Mahanty, Daniel P. Fedorko, John Edward Janik, John C. Morris

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalActa Haematologica
Volume126
Issue number2
DOIs
StatePublished - Aug 1 2011

Fingerprint

Strongyloides stercoralis
Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
T-Lymphocytes
Adrenal Cortex Hormones
Infection
Albendazole
Ivermectin
Anthelmintics
Exanthema
Cough
Vomiting
Diarrhea
Fever
Therapeutics
Monoclonal Antibodies
Clinical Trials
alemtuzumab

Keywords

  • Adult T-cell leukemia
  • Alemtuzumab
  • Corticosteroid
  • Disseminated Strongyloides
  • HTLV-1
  • Human T-cell lymphotropic virus type-1

ASJC Scopus subject areas

  • Hematology

Cite this

Stewart, D. M., Ramanathan, R., Mahanty, S., Fedorko, D. P., Janik, J. E., & Morris, J. C. (2011). Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma. Acta Haematologica, 126(2), 63-67. https://doi.org/10.1159/000324799

Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma. / Stewart, Donn M.; Ramanathan, Roshan; Mahanty, Siddhartha; Fedorko, Daniel P.; Janik, John Edward; Morris, John C.

In: Acta Haematologica, Vol. 126, No. 2, 01.08.2011, p. 63-67.

Research output: Contribution to journalArticle

Stewart, DM, Ramanathan, R, Mahanty, S, Fedorko, DP, Janik, JE & Morris, JC 2011, 'Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma', Acta Haematologica, vol. 126, no. 2, pp. 63-67. https://doi.org/10.1159/000324799
Stewart, Donn M. ; Ramanathan, Roshan ; Mahanty, Siddhartha ; Fedorko, Daniel P. ; Janik, John Edward ; Morris, John C. / Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma. In: Acta Haematologica. 2011 ; Vol. 126, No. 2. pp. 63-67.
@article{c12748bcc8a4453da75690d005ce7d8a,
title = "Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma",
abstract = "A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.",
keywords = "Adult T-cell leukemia, Alemtuzumab, Corticosteroid, Disseminated Strongyloides, HTLV-1, Human T-cell lymphotropic virus type-1",
author = "Stewart, {Donn M.} and Roshan Ramanathan and Siddhartha Mahanty and Fedorko, {Daniel P.} and Janik, {John Edward} and Morris, {John C.}",
year = "2011",
month = "8",
day = "1",
doi = "10.1159/000324799",
language = "English (US)",
volume = "126",
pages = "63--67",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma

AU - Stewart, Donn M.

AU - Ramanathan, Roshan

AU - Mahanty, Siddhartha

AU - Fedorko, Daniel P.

AU - Janik, John Edward

AU - Morris, John C.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.

AB - A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.

KW - Adult T-cell leukemia

KW - Alemtuzumab

KW - Corticosteroid

KW - Disseminated Strongyloides

KW - HTLV-1

KW - Human T-cell lymphotropic virus type-1

UR - http://www.scopus.com/inward/record.url?scp=79953674826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953674826&partnerID=8YFLogxK

U2 - 10.1159/000324799

DO - 10.1159/000324799

M3 - Article

C2 - 21474923

AN - SCOPUS:79953674826

VL - 126

SP - 63

EP - 67

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 2

ER -