Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma

Donn M. Stewart, Roshan Ramanathan, Siddhartha Mahanty, Daniel P. Fedorko, John Edward Janik, John C. Morris

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalActa Haematologica
Volume126
Issue number2
DOIs
StatePublished - Aug 1 2011

    Fingerprint

Keywords

  • Adult T-cell leukemia
  • Alemtuzumab
  • Corticosteroid
  • Disseminated Strongyloides
  • HTLV-1
  • Human T-cell lymphotropic virus type-1

ASJC Scopus subject areas

  • Hematology

Cite this

Stewart, D. M., Ramanathan, R., Mahanty, S., Fedorko, D. P., Janik, J. E., & Morris, J. C. (2011). Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma. Acta Haematologica, 126(2), 63-67. https://doi.org/10.1159/000324799