@article{125845de69174e23b18c760dda61e63d,
title = "Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler's virus infection",
abstract = "We established a novel model of myocarditis induced with Theiler's murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while C57BL/6 mice had mild lesions and SJL/J mice had no inflammation in the heart. In C3H mice, myocarditis was divided into three phases: acute viral, subacute immune, and chronic fibrotic phases. Using toll-like receptor (TLR) 4-deficient C3H mice, we found that interleukin (IL)-6, IL-17, TLR4, and anti-viral immune responses were associated with myocarditis susceptibility.",
keywords = "Autoimmunity, CNS demyelinating disease, Echocardiography, Fibrosis, IL-6, Infectious disease, Picornaviridae infection, Toll-like receptor, Tropism, Troponin",
author = "Fumitaka Sato and Seiichi Omura and Eiichiro Kawai and Martinez, {Nicholas E.} and Acharya, {Madan M.} and Reddy, {Pratap C.} and Chaitanya, {Ganta V.} and Alexander, {J. Steven} and Ikuo Tsunoda",
note = "Funding Information: This work was supported by the fellowships (F. Sato and S. Omura) from the Malcolm Feist Cardiovascular Research Endowment, Louisiana State University Health Sciences Center, Shreveport, and grants from the Department of Defence (PR100451, J.S. Alexander), the National Center for Research Resources of the National Institutes of Health (5P20RR018724, I. Tsunoda), and the National Institute of General Medical Sciences COBRE Grant (P30-GM110703, I. Tsunoda). We thank Drs. Noel G. Carlson, John W. Rose, Hong-Hua Mu, Masaaki Miyazawa, Fereidoon Shafiei, and Liam A. Morris for many helpful discussions and Sadie Faith Pearson, Lesya Ekshyyan, Elaine A. Cliburn, and Christi L. Eugene for excellent technical assistances. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",
year = "2014",
month = nov,
day = "1",
doi = "10.1016/j.cellimm.2014.10.004",
language = "English (US)",
volume = "292",
pages = "85--93",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1-2",
}