Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler's virus infection

Fumitaka Sato, Seiichi Omura, Eiichiro Kawai, Nicholas E. Martinez, Madan M. Acharya, Pratap C. Reddy, Ganta V. Chaitanya, J. Steven Alexander, Ikuo Tsunoda

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We established a novel model of myocarditis induced with Theiler's murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while C57BL/6 mice had mild lesions and SJL/J mice had no inflammation in the heart. In C3H mice, myocarditis was divided into three phases: acute viral, subacute immune, and chronic fibrotic phases. Using toll-like receptor (TLR) 4-deficient C3H mice, we found that interleukin (IL)-6, IL-17, TLR4, and anti-viral immune responses were associated with myocarditis susceptibility.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalCellular Immunology
Volume292
Issue number1-2
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • Autoimmunity
  • CNS demyelinating disease
  • Echocardiography
  • Fibrosis
  • IL-6
  • Infectious disease
  • Picornaviridae infection
  • Toll-like receptor
  • Tropism
  • Troponin

ASJC Scopus subject areas

  • Immunology

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