Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1

Sreedharan Sajikumar, Sheeja Navakkode, Julietta U. Frey

Research output: Contribution to journalArticle

19 Scopus citations


The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.

Original languageEnglish (US)
Pages (from-to)46-49
Number of pages4
JournalLearning and Memory
Issue number2
Publication statusPublished - Feb 1 2008


ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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