Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1

Sreedharan Sajikumar, Sheeja Navakkode, Julietta U. Frey

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.

Original languageEnglish (US)
Pages (from-to)46-49
Number of pages4
JournalLearning and Memory
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2008

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Tetanus
Learning
Long-Term Potentiation
Proteins

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1. / Sajikumar, Sreedharan; Navakkode, Sheeja; Frey, Julietta U.

In: Learning and Memory, Vol. 15, No. 2, 01.02.2008, p. 46-49.

Research output: Contribution to journalArticle

Sajikumar, Sreedharan ; Navakkode, Sheeja ; Frey, Julietta U. / Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1. In: Learning and Memory. 2008 ; Vol. 15, No. 2. pp. 46-49.
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