Distraction osteogenesis in irradiated rabbit mandibles with adjunctive hyperbaric oxygen therapy

Charles L. Clark, James Strider, Chris Hall, Henry W. Ferguson, Karyn L. Armstrong, Royce R. Runner, Dale A. Baur

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to evaluate the effect of hyperbaric oxygen therapy on bone regeneration during distraction of irradiated rabbit mandibles. Materials and Methods: Twenty New Zealand white rabbits were randomly sub-divided into 4 groups. Group 1 served as control, group 2 received preoperative radiation therapy, group 3 received pre- and postoperative hyperbaric oxygen (HBO) therapy, and group 4 received preoperative radiation therapy and pre- and postoperative HBO therapy. All rabbits underwent a corticotomy of the left body of the mandible after placement of a distraction device. Distraction, at a rate of 1 mm/day and a rhythm of 1 turn/day, began after a 3-day latency period for 14 days. Thirty days after completion of the distraction protocol, the animals were euthanized, and histomorphometric and radiographic data of the distraction segments were obtained. Results: Histomorphometric analysis of new bone fill was greatest in the non-irradiated groups compared to groups receiving radiation therapy, regardless of HBO therapy (P = .03). Pre-corticotomy bone density measurements showed a significant increase in bone density over time (P = .0007). This resulted in a significant relationship between HBO therapy, radiation therapy, and time (P = .0050). Conclusions: The results of the study support the use of HBO therapy during distraction osteogenesis. Any additional therapeutic benefit of HBO therapy in irradiated bone would require additional investigation.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalJournal of Oral and Maxillofacial Surgery
Volume64
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Distraction Osteogenesis
Hyperbaric Oxygenation
Mandible
Rabbits
Radiotherapy
Bone Density
Bone and Bones
Bone Regeneration
Equipment and Supplies
Control Groups

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Distraction osteogenesis in irradiated rabbit mandibles with adjunctive hyperbaric oxygen therapy. / Clark, Charles L.; Strider, James; Hall, Chris; Ferguson, Henry W.; Armstrong, Karyn L.; Runner, Royce R.; Baur, Dale A.

In: Journal of Oral and Maxillofacial Surgery, Vol. 64, No. 4, 01.04.2006, p. 589-593.

Research output: Contribution to journalArticle

Clark, Charles L. ; Strider, James ; Hall, Chris ; Ferguson, Henry W. ; Armstrong, Karyn L. ; Runner, Royce R. ; Baur, Dale A. / Distraction osteogenesis in irradiated rabbit mandibles with adjunctive hyperbaric oxygen therapy. In: Journal of Oral and Maxillofacial Surgery. 2006 ; Vol. 64, No. 4. pp. 589-593.
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