Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

Ali Amro, Yalei Chen, Renee Barry, Laura Susick, Jessica Bensenhaver, Erica Proctor, Lindsay Petersen, S. David Nathanson, Haythem Ali, Randa Loutfi, Dhananjay Chitale, Alyson Simonds, Marcia Kuklinski, Ko Un Park, Melissa Davis, Lisa A. Newman

Research output: Contribution to journalArticle

Abstract

We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalBreast Journal
Volume25
Issue number4
DOIs
StatePublished - Jul 1 2019

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Keywords

  • Oncotype DX
  • breast cancer
  • disparities

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

Cite this

Amro, A., Chen, Y., Barry, R., Susick, L., Bensenhaver, J., Proctor, E., Petersen, L., Nathanson, S. D., Ali, H., Loutfi, R., Chitale, D., Simonds, A., Kuklinski, M., Park, K. U., Davis, M., & Newman, L. A. (2019). Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients. Breast Journal, 25(4), 667-671. https://doi.org/10.1111/tbj.13256