Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

Ali Amro, Yalei Chen, Renee Barry, Laura Susick, Jessica Bensenhaver, Erica Proctor, Lindsay Petersen, S. David Nathanson, Haythem Ali, Randa Loutfi, Dhananjay Chitale, Alyson Simonds, Marcia Kuklinski, Ko Un Park, Melissa B Davis, Lisa A. Newman

Research output: Contribution to journalArticle

Abstract

We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalBreast Journal
Volume25
Issue number4
DOIs
StatePublished - Jul 1 2019

Fingerprint

African Americans
Breast Neoplasms
Recurrence
Genes
Hormones
Drug Therapy
Neoplasms

Keywords

  • Oncotype DX
  • breast cancer
  • disparities

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

Cite this

Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients. / Amro, Ali; Chen, Yalei; Barry, Renee; Susick, Laura; Bensenhaver, Jessica; Proctor, Erica; Petersen, Lindsay; Nathanson, S. David; Ali, Haythem; Loutfi, Randa; Chitale, Dhananjay; Simonds, Alyson; Kuklinski, Marcia; Park, Ko Un; Davis, Melissa B; Newman, Lisa A.

In: Breast Journal, Vol. 25, No. 4, 01.07.2019, p. 667-671.

Research output: Contribution to journalArticle

Amro, A, Chen, Y, Barry, R, Susick, L, Bensenhaver, J, Proctor, E, Petersen, L, Nathanson, SD, Ali, H, Loutfi, R, Chitale, D, Simonds, A, Kuklinski, M, Park, KU, Davis, MB & Newman, LA 2019, 'Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients', Breast Journal, vol. 25, no. 4, pp. 667-671. https://doi.org/10.1111/tbj.13256
Amro, Ali ; Chen, Yalei ; Barry, Renee ; Susick, Laura ; Bensenhaver, Jessica ; Proctor, Erica ; Petersen, Lindsay ; Nathanson, S. David ; Ali, Haythem ; Loutfi, Randa ; Chitale, Dhananjay ; Simonds, Alyson ; Kuklinski, Marcia ; Park, Ko Un ; Davis, Melissa B ; Newman, Lisa A. / Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients. In: Breast Journal. 2019 ; Vol. 25, No. 4. pp. 667-671.
@article{1b4257f1fb90432da51fe6726cccac16,
title = "Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients",
abstract = "We evaluated 328 patients (34.8{\%} African American [AA]; 65.2{\%} White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3{\%} AA and 5.9{\%} WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0{\%} and 1.6{\%}, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.",
keywords = "Oncotype DX, breast cancer, disparities",
author = "Ali Amro and Yalei Chen and Renee Barry and Laura Susick and Jessica Bensenhaver and Erica Proctor and Lindsay Petersen and Nathanson, {S. David} and Haythem Ali and Randa Loutfi and Dhananjay Chitale and Alyson Simonds and Marcia Kuklinski and Park, {Ko Un} and Davis, {Melissa B} and Newman, {Lisa A.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1111/tbj.13256",
language = "English (US)",
volume = "25",
pages = "667--671",
journal = "Breast Journal",
issn = "1075-122X",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients

AU - Amro, Ali

AU - Chen, Yalei

AU - Barry, Renee

AU - Susick, Laura

AU - Bensenhaver, Jessica

AU - Proctor, Erica

AU - Petersen, Lindsay

AU - Nathanson, S. David

AU - Ali, Haythem

AU - Loutfi, Randa

AU - Chitale, Dhananjay

AU - Simonds, Alyson

AU - Kuklinski, Marcia

AU - Park, Ko Un

AU - Davis, Melissa B

AU - Newman, Lisa A.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.

AB - We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.

KW - Oncotype DX

KW - breast cancer

KW - disparities

UR - http://www.scopus.com/inward/record.url?scp=85064808285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064808285&partnerID=8YFLogxK

U2 - 10.1111/tbj.13256

DO - 10.1111/tbj.13256

M3 - Article

VL - 25

SP - 667

EP - 671

JO - Breast Journal

JF - Breast Journal

SN - 1075-122X

IS - 4

ER -