Abstract
We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 667-671 |
| Number of pages | 5 |
| Journal | Breast Journal |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2019 |
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Keywords
- Oncotype DX
- breast cancer
- disparities
ASJC Scopus subject areas
- Internal Medicine
- Surgery
- Oncology
Cite this
Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients. / Amro, Ali; Chen, Yalei; Barry, Renee; Susick, Laura; Bensenhaver, Jessica; Proctor, Erica; Petersen, Lindsay; Nathanson, S. David; Ali, Haythem; Loutfi, Randa; Chitale, Dhananjay; Simonds, Alyson; Kuklinski, Marcia; Park, Ko Un; Davis, Melissa B; Newman, Lisa A.
In: Breast Journal, Vol. 25, No. 4, 01.07.2019, p. 667-671.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients
AU - Amro, Ali
AU - Chen, Yalei
AU - Barry, Renee
AU - Susick, Laura
AU - Bensenhaver, Jessica
AU - Proctor, Erica
AU - Petersen, Lindsay
AU - Nathanson, S. David
AU - Ali, Haythem
AU - Loutfi, Randa
AU - Chitale, Dhananjay
AU - Simonds, Alyson
AU - Kuklinski, Marcia
AU - Park, Ko Un
AU - Davis, Melissa B
AU - Newman, Lisa A.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.
AB - We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.
KW - Oncotype DX
KW - breast cancer
KW - disparities
UR - http://www.scopus.com/inward/record.url?scp=85064808285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064808285&partnerID=8YFLogxK
U2 - 10.1111/tbj.13256
DO - 10.1111/tbj.13256
M3 - Article
C2 - 31025467
AN - SCOPUS:85064808285
VL - 25
SP - 667
EP - 671
JO - Breast Journal
JF - Breast Journal
SN - 1075-122X
IS - 4
ER -