Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

Miyuki Tauchi, Rong Zhang, David A. D'Alessio, Javier Eduardo Stern, James P. Herman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalJournal of Chemical Neuroanatomy
Volume36
Issue number3-4
DOIs
StatePublished - Dec 1 2008

Fingerprint

Supraoptic Nucleus
Glucagon-Like Peptide 1
Paraventricular Hypothalamic Nucleus
Neurons
Neuroendocrine Cells
Solitary Nucleus
Corticotropin-Releasing Hormone
Oxytocin
Adrenocorticotropic Hormone
Brain Stem

Keywords

  • Arginine vasopressin
  • Corticotrophin releasing hormone
  • Fluorogold
  • Nucleus of the solitary tract
  • Oxytocin
  • Pre-autonomic
  • Retrograde tracing

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. / Tauchi, Miyuki; Zhang, Rong; D'Alessio, David A.; Stern, Javier Eduardo; Herman, James P.

In: Journal of Chemical Neuroanatomy, Vol. 36, No. 3-4, 01.12.2008, p. 144-149.

Research output: Contribution to journalArticle

Tauchi, Miyuki ; Zhang, Rong ; D'Alessio, David A. ; Stern, Javier Eduardo ; Herman, James P. / Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. In: Journal of Chemical Neuroanatomy. 2008 ; Vol. 36, No. 3-4. pp. 144-149.
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