Distribution of Mahogany/Attractin mRNA in the rat central nervous system

Xin Yun Lu; Teresa M. Gunn; Kun Ruey Shieh; Gregory S. Barsh; Huda Akil; Stanley J. Watson

doi:10.1016/S0014-5793(99)01494-5

Distribution of Mahogany/Attractin mRNA in the rat central nervous system

Xin Yun Lu, Teresa M. Gunn, Kun Ruey Shieh, Gregory S. Barsh, Huda Akil, Stanley J. Watson

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The Mahogany/Attractin gene (Atrn) has been proposed as a downstream mediator of Agouti signaling because yellow hair color and obesity in lethal yellow (A(y)) mice are suppressed by the mahogany (Atrn(mg)) mutation. The present study examined the distribution of Atrn mRNA in the brain and spinal cord by in situ hybridization. Atrn mRNA was found widely distributed throughout the central nervous system, with high levels in regions of the olfactory system, some limbic structures, regions of the brainstem, cerebellum and spinal cord. In the hypothalamus, Atrn mRNA was found in specific nuclei including the suprachiasmatic nucleus, the supraoptic nucleus, the medial preoptic nucleus, the paraventricular hypothalamic nucleus, the ventromedial hypothalamic nucleus, and the arcuate nucleus. These results suggest a broad spectrum of physiological functions for the Atrn gene product.

Original language	English (US)
Pages (from-to)	101-107
Number of pages	7
Journal	FEBS Letters
Volume	462
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(99)01494-5
State	Published - Nov 26 1999
Externally published	Yes

Keywords

Agouti
Brain
In situ hybridization
Mahogany/Attractin
Obesity
Spinal cord

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0014-5793(99)01494-5

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title = "Distribution of Mahogany/Attractin mRNA in the rat central nervous system",

abstract = "The Mahogany/Attractin gene (Atrn) has been proposed as a downstream mediator of Agouti signaling because yellow hair color and obesity in lethal yellow (A(y)) mice are suppressed by the mahogany (Atrn(mg)) mutation. The present study examined the distribution of Atrn mRNA in the brain and spinal cord by in situ hybridization. Atrn mRNA was found widely distributed throughout the central nervous system, with high levels in regions of the olfactory system, some limbic structures, regions of the brainstem, cerebellum and spinal cord. In the hypothalamus, Atrn mRNA was found in specific nuclei including the suprachiasmatic nucleus, the supraoptic nucleus, the medial preoptic nucleus, the paraventricular hypothalamic nucleus, the ventromedial hypothalamic nucleus, and the arcuate nucleus. These results suggest a broad spectrum of physiological functions for the Atrn gene product.",

keywords = "Agouti, Brain, In situ hybridization, Mahogany/Attractin, Obesity, Spinal cord",

author = "Lu, {Xin Yun} and Gunn, {Teresa M.} and Shieh, {Kun Ruey} and Barsh, {Gregory S.} and Huda Akil and Watson, {Stanley J.}",

note = "Funding Information: This work was supported by a Grant from the University of Michigan GI center to S.J.W. (P30DK34933) and by Grants from the National Institutes of Health to S.J.W. and H.A. (MH42251) and to G.S.B. (DK28506). G.S.B. is an Associate Investigator of the Howard Hughes Medical Institute. ",

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doi = "10.1016/S0014-5793(99)01494-5",

language = "English (US)",

volume = "462",

pages = "101--107",

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T1 - Distribution of Mahogany/Attractin mRNA in the rat central nervous system

AU - Lu, Xin Yun

AU - Gunn, Teresa M.

AU - Shieh, Kun Ruey

AU - Barsh, Gregory S.

AU - Akil, Huda

AU - Watson, Stanley J.

N1 - Funding Information: This work was supported by a Grant from the University of Michigan GI center to S.J.W. (P30DK34933) and by Grants from the National Institutes of Health to S.J.W. and H.A. (MH42251) and to G.S.B. (DK28506). G.S.B. is an Associate Investigator of the Howard Hughes Medical Institute.

PY - 1999/11/26

Y1 - 1999/11/26

N2 - The Mahogany/Attractin gene (Atrn) has been proposed as a downstream mediator of Agouti signaling because yellow hair color and obesity in lethal yellow (A(y)) mice are suppressed by the mahogany (Atrn(mg)) mutation. The present study examined the distribution of Atrn mRNA in the brain and spinal cord by in situ hybridization. Atrn mRNA was found widely distributed throughout the central nervous system, with high levels in regions of the olfactory system, some limbic structures, regions of the brainstem, cerebellum and spinal cord. In the hypothalamus, Atrn mRNA was found in specific nuclei including the suprachiasmatic nucleus, the supraoptic nucleus, the medial preoptic nucleus, the paraventricular hypothalamic nucleus, the ventromedial hypothalamic nucleus, and the arcuate nucleus. These results suggest a broad spectrum of physiological functions for the Atrn gene product.

AB - The Mahogany/Attractin gene (Atrn) has been proposed as a downstream mediator of Agouti signaling because yellow hair color and obesity in lethal yellow (A(y)) mice are suppressed by the mahogany (Atrn(mg)) mutation. The present study examined the distribution of Atrn mRNA in the brain and spinal cord by in situ hybridization. Atrn mRNA was found widely distributed throughout the central nervous system, with high levels in regions of the olfactory system, some limbic structures, regions of the brainstem, cerebellum and spinal cord. In the hypothalamus, Atrn mRNA was found in specific nuclei including the suprachiasmatic nucleus, the supraoptic nucleus, the medial preoptic nucleus, the paraventricular hypothalamic nucleus, the ventromedial hypothalamic nucleus, and the arcuate nucleus. These results suggest a broad spectrum of physiological functions for the Atrn gene product.

KW - Agouti

KW - Brain

KW - In situ hybridization

KW - Mahogany/Attractin

KW - Obesity

KW - Spinal cord

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Distribution of Mahogany/Attractin mRNA in the rat central nervous system

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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