Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: Relationship to other populations

Bo Feng Zhu, Guang Yang, Chun Mei Shen, Hai Xia Qin, Shun Zhi Liu, Ya Jun Deng, Shuan Liang Fan, Li Bin Deng, Feng Chen, Ping Zhang, Jie Fang, Li Ping Chen, Hong Dan Wang, Zhen Yuan Wang, Rudolf Lucas

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalJournal of Zhejiang University: Science B
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

HLA Antigens
Haplotypes
China
haplotypes
Alleles
alleles
Population
loci
HLA antigens
Forensic Sciences
bone marrow transplant
Anthropology
DNA Fingerprinting
Polymerase chain reaction
nationalities and ethnic groups
Polymorphism
DNA fingerprinting
Bone Marrow Transplantation
Ethnic Groups
gene frequency

Keywords

  • Allele
  • HLA-B
  • Haplotype
  • Human leukocyte antigen (HLA)-A
  • Polymerase chain reaction-sequence-based typing (PCR-SBT)
  • Yi ethnic minority

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China : Relationship to other populations. / Zhu, Bo Feng; Yang, Guang; Shen, Chun Mei; Qin, Hai Xia; Liu, Shun Zhi; Deng, Ya Jun; Fan, Shuan Liang; Deng, Li Bin; Chen, Feng; Zhang, Ping; Fang, Jie; Chen, Li Ping; Wang, Hong Dan; Wang, Zhen Yuan; Lucas, Rudolf.

In: Journal of Zhejiang University: Science B, Vol. 11, No. 2, 01.02.2010, p. 127-135.

Research output: Contribution to journalArticle

Zhu, BF, Yang, G, Shen, CM, Qin, HX, Liu, SZ, Deng, YJ, Fan, SL, Deng, LB, Chen, F, Zhang, P, Fang, J, Chen, LP, Wang, HD, Wang, ZY & Lucas, R 2010, 'Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: Relationship to other populations', Journal of Zhejiang University: Science B, vol. 11, no. 2, pp. 127-135. https://doi.org/10.1631/jzus.B0900232
Zhu, Bo Feng ; Yang, Guang ; Shen, Chun Mei ; Qin, Hai Xia ; Liu, Shun Zhi ; Deng, Ya Jun ; Fan, Shuan Liang ; Deng, Li Bin ; Chen, Feng ; Zhang, Ping ; Fang, Jie ; Chen, Li Ping ; Wang, Hong Dan ; Wang, Zhen Yuan ; Lucas, Rudolf. / Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China : Relationship to other populations. In: Journal of Zhejiang University: Science B. 2010 ; Vol. 11, No. 2. pp. 127-135.
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abstract = "Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46{\%}), A1101 (26.32{\%}), and A0203 (10.09{\%}) at the HLA-A locus and B4601 (12.28{\%}), B1525 (10.09{\%}), B4001 (8.77{\%}), and B3802 (7.89{\%}) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86{\%}) and A0203-B3802 (5.64{\%}), followed by A1101-B4001 (4.69{\%}). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.",
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T1 - Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China

T2 - Relationship to other populations

AU - Zhu, Bo Feng

AU - Yang, Guang

AU - Shen, Chun Mei

AU - Qin, Hai Xia

AU - Liu, Shun Zhi

AU - Deng, Ya Jun

AU - Fan, Shuan Liang

AU - Deng, Li Bin

AU - Chen, Feng

AU - Zhang, Ping

AU - Fang, Jie

AU - Chen, Li Ping

AU - Wang, Hong Dan

AU - Wang, Zhen Yuan

AU - Lucas, Rudolf

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N2 - Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

AB - Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

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KW - Haplotype

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KW - Polymerase chain reaction-sequence-based typing (PCR-SBT)

KW - Yi ethnic minority

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