Diversity of Killer Cell Immunoglobulin-like Receptor Genes in the Bai Ethnic Minority of Yunnan, China

B. F. Zhu, H. D. Wang, C. M. Shen, A. Y. Fan, G. Yang, H. X. Qin, T. B. Jin, T. Xie, L. Deng, Rudolf Lucas, Z. M. Lian

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Killer cell immunoglobulin-like receptors (KIRs), expressed in both natural killer (NK) cells and a subset of T cells, represent a family of both inhibitory and activating receptors that can regulate NK and T cells upon interacting with human leucocyte antigen (HLA) class I molecules on target cells. The number and distribution of KIR genes vary between individuals and populations from different geographical regions and ethnic origins. In this study, we investigated KIR gene frequencies and genotype diversities of 13 KIR genes, 2 pseudogenes, expressed and non-expressed forms of KIR2DL5 and the two subtypes, full-length and deleted forms, of KIR2DS4 in 100 unrelated healthy individuals of the Bai population, living in the Dali Bai autonomous prefecture in the Yunnan province. All individuals were typed positive for the three framework loci KIR3DL3, 2DL4 and 3DL2, as well as for three non-framework genes KIR2DL1, 2DL3 and the pseudogene KIR2DP1. The gene frequencies of the other KIR genes ranged from 7%-95%. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that they display a wide range of LD. χ2 analysis among non-ubiquitous genes, using the KIR gene frequency data from our study population, as well as from previously published population data, was conducted and revealed significant differences in the KIR2DL1, 2DL2, 3DL1 and KIR2DS1 genes. The results of the present study can be valuable for enriching the Chinese ethnical gene information resources of the KIR gene pool, for anthropological studies, as well as for KIR-related disease research.

Original languageEnglish (US)
Pages (from-to)284-292
Number of pages9
JournalScandinavian Journal of Immunology
Volume73
Issue number4
DOIs
StatePublished - Apr 1 2011

Fingerprint

KIR Receptors
China
Genes
Gene Frequency
Pseudogenes
Linkage Disequilibrium
Population
Gene Pool
Natural Killer T-Cells
Anthropology
T-Lymphocyte Subsets
HLA Antigens
Natural Killer Cells
Genotype

ASJC Scopus subject areas

  • Immunology

Cite this

Diversity of Killer Cell Immunoglobulin-like Receptor Genes in the Bai Ethnic Minority of Yunnan, China. / Zhu, B. F.; Wang, H. D.; Shen, C. M.; Fan, A. Y.; Yang, G.; Qin, H. X.; Jin, T. B.; Xie, T.; Deng, L.; Lucas, Rudolf; Lian, Z. M.

In: Scandinavian Journal of Immunology, Vol. 73, No. 4, 01.04.2011, p. 284-292.

Research output: Contribution to journalArticle

Zhu, BF, Wang, HD, Shen, CM, Fan, AY, Yang, G, Qin, HX, Jin, TB, Xie, T, Deng, L, Lucas, R & Lian, ZM 2011, 'Diversity of Killer Cell Immunoglobulin-like Receptor Genes in the Bai Ethnic Minority of Yunnan, China', Scandinavian Journal of Immunology, vol. 73, no. 4, pp. 284-292. https://doi.org/10.1111/j.1365-3083.2011.02508.x
Zhu, B. F. ; Wang, H. D. ; Shen, C. M. ; Fan, A. Y. ; Yang, G. ; Qin, H. X. ; Jin, T. B. ; Xie, T. ; Deng, L. ; Lucas, Rudolf ; Lian, Z. M. / Diversity of Killer Cell Immunoglobulin-like Receptor Genes in the Bai Ethnic Minority of Yunnan, China. In: Scandinavian Journal of Immunology. 2011 ; Vol. 73, No. 4. pp. 284-292.
@article{31faed5d8c554c8e851f602d6d824f63,
title = "Diversity of Killer Cell Immunoglobulin-like Receptor Genes in the Bai Ethnic Minority of Yunnan, China",
abstract = "Killer cell immunoglobulin-like receptors (KIRs), expressed in both natural killer (NK) cells and a subset of T cells, represent a family of both inhibitory and activating receptors that can regulate NK and T cells upon interacting with human leucocyte antigen (HLA) class I molecules on target cells. The number and distribution of KIR genes vary between individuals and populations from different geographical regions and ethnic origins. In this study, we investigated KIR gene frequencies and genotype diversities of 13 KIR genes, 2 pseudogenes, expressed and non-expressed forms of KIR2DL5 and the two subtypes, full-length and deleted forms, of KIR2DS4 in 100 unrelated healthy individuals of the Bai population, living in the Dali Bai autonomous prefecture in the Yunnan province. All individuals were typed positive for the three framework loci KIR3DL3, 2DL4 and 3DL2, as well as for three non-framework genes KIR2DL1, 2DL3 and the pseudogene KIR2DP1. The gene frequencies of the other KIR genes ranged from 7{\%}-95{\%}. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that they display a wide range of LD. χ2 analysis among non-ubiquitous genes, using the KIR gene frequency data from our study population, as well as from previously published population data, was conducted and revealed significant differences in the KIR2DL1, 2DL2, 3DL1 and KIR2DS1 genes. The results of the present study can be valuable for enriching the Chinese ethnical gene information resources of the KIR gene pool, for anthropological studies, as well as for KIR-related disease research.",
author = "Zhu, {B. F.} and Wang, {H. D.} and Shen, {C. M.} and Fan, {A. Y.} and G. Yang and Qin, {H. X.} and Jin, {T. B.} and T. Xie and L. Deng and Rudolf Lucas and Lian, {Z. M.}",
year = "2011",
month = "4",
day = "1",
doi = "10.1111/j.1365-3083.2011.02508.x",
language = "English (US)",
volume = "73",
pages = "284--292",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Diversity of Killer Cell Immunoglobulin-like Receptor Genes in the Bai Ethnic Minority of Yunnan, China

AU - Zhu, B. F.

AU - Wang, H. D.

AU - Shen, C. M.

AU - Fan, A. Y.

AU - Yang, G.

AU - Qin, H. X.

AU - Jin, T. B.

AU - Xie, T.

AU - Deng, L.

AU - Lucas, Rudolf

AU - Lian, Z. M.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Killer cell immunoglobulin-like receptors (KIRs), expressed in both natural killer (NK) cells and a subset of T cells, represent a family of both inhibitory and activating receptors that can regulate NK and T cells upon interacting with human leucocyte antigen (HLA) class I molecules on target cells. The number and distribution of KIR genes vary between individuals and populations from different geographical regions and ethnic origins. In this study, we investigated KIR gene frequencies and genotype diversities of 13 KIR genes, 2 pseudogenes, expressed and non-expressed forms of KIR2DL5 and the two subtypes, full-length and deleted forms, of KIR2DS4 in 100 unrelated healthy individuals of the Bai population, living in the Dali Bai autonomous prefecture in the Yunnan province. All individuals were typed positive for the three framework loci KIR3DL3, 2DL4 and 3DL2, as well as for three non-framework genes KIR2DL1, 2DL3 and the pseudogene KIR2DP1. The gene frequencies of the other KIR genes ranged from 7%-95%. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that they display a wide range of LD. χ2 analysis among non-ubiquitous genes, using the KIR gene frequency data from our study population, as well as from previously published population data, was conducted and revealed significant differences in the KIR2DL1, 2DL2, 3DL1 and KIR2DS1 genes. The results of the present study can be valuable for enriching the Chinese ethnical gene information resources of the KIR gene pool, for anthropological studies, as well as for KIR-related disease research.

AB - Killer cell immunoglobulin-like receptors (KIRs), expressed in both natural killer (NK) cells and a subset of T cells, represent a family of both inhibitory and activating receptors that can regulate NK and T cells upon interacting with human leucocyte antigen (HLA) class I molecules on target cells. The number and distribution of KIR genes vary between individuals and populations from different geographical regions and ethnic origins. In this study, we investigated KIR gene frequencies and genotype diversities of 13 KIR genes, 2 pseudogenes, expressed and non-expressed forms of KIR2DL5 and the two subtypes, full-length and deleted forms, of KIR2DS4 in 100 unrelated healthy individuals of the Bai population, living in the Dali Bai autonomous prefecture in the Yunnan province. All individuals were typed positive for the three framework loci KIR3DL3, 2DL4 and 3DL2, as well as for three non-framework genes KIR2DL1, 2DL3 and the pseudogene KIR2DP1. The gene frequencies of the other KIR genes ranged from 7%-95%. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that they display a wide range of LD. χ2 analysis among non-ubiquitous genes, using the KIR gene frequency data from our study population, as well as from previously published population data, was conducted and revealed significant differences in the KIR2DL1, 2DL2, 3DL1 and KIR2DS1 genes. The results of the present study can be valuable for enriching the Chinese ethnical gene information resources of the KIR gene pool, for anthropological studies, as well as for KIR-related disease research.

UR - http://www.scopus.com/inward/record.url?scp=79952064252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952064252&partnerID=8YFLogxK

U2 - 10.1111/j.1365-3083.2011.02508.x

DO - 10.1111/j.1365-3083.2011.02508.x

M3 - Article

VL - 73

SP - 284

EP - 292

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 4

ER -