DL-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury

Y. Mythili, Sudharsan Periyasamy Thandavan, P. Varalakshmi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mitochondria play a central role in heart metabolism and function. Administration of antineoplastic drug cyclophosphamide (CP) adversely affects the heart mitochondria which may result in cardiotoxicity. The present study is aimed at evaluating the role of lipoic acid (LA) in CP induced myocardial injury. Male albino rats of Wistar strain were used for the study. CP was administered as a single intraperitoneal injection (200 mg/kg BW). A decrease in the activities of TCA cycle enzymes such as succinate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase was noted in CP treated rats. Simultaneously there was a decrease in the activities of mitochondrial complexes of electron transport chain. Decrease in the activities of these enzymes suggests a loss in mitochondrial function and integrity. Ultrastuctural observations were also in agreement with the above abnormal changes. Loss of myofilaments and damage of mitochondrial cristae revealed the cytotoxic effect of CP. The supplementation of LA (25 mg/kg BW) restored the above abnormalities to near normalcy. The study brings out the importance of LA in improving the mitochondrial function in cardiac cells after CP administration.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalToxicology
Volume215
Issue number1-2
DOIs
StatePublished - Nov 15 2005

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Thioctic Acid
Cyclophosphamide
Wounds and Injuries
Mitochondria
Rats
Activity Cycles
Isocitrate Dehydrogenase
Heart Mitochondria
Malate Dehydrogenase
Succinate Dehydrogenase
Myofibrils
Enzymes
Electron Transport
Intraperitoneal Injections
Metabolism
Antineoplastic Agents
Wistar Rats

Keywords

  • Cyclophosphamide
  • Heart
  • Lipoic acid
  • Mitochondrial enzymes
  • Ultrastructure

ASJC Scopus subject areas

  • Toxicology

Cite this

DL-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury. / Mythili, Y.; Periyasamy Thandavan, Sudharsan; Varalakshmi, P.

In: Toxicology, Vol. 215, No. 1-2, 15.11.2005, p. 108-114.

Research output: Contribution to journalArticle

Mythili, Y, Periyasamy Thandavan, S & Varalakshmi, P 2005, 'DL-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury', Toxicology, vol. 215, no. 1-2, pp. 108-114. https://doi.org/10.1016/j.tox.2005.07.001
Mythili, Y. ; Periyasamy Thandavan, Sudharsan ; Varalakshmi, P. / DL-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury. In: Toxicology. 2005 ; Vol. 215, No. 1-2. pp. 108-114.
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