DNA-BAR: Distinguisher selection for DNA barcoding

B. DasGupta, K. M. Konwar, Ion I. Mǎndoiu, A. A. Shvartsman

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Summary: DNA-BAR is a software package for selecting DNA probes (henceforth referred to as distinguishers) that can be used in genomic-based identification of microorganisms. Given the genomic sequences of the microorganisms, DNA-BAR finds a near-minimum number of distinguishers yielding a distinct hybridization pattern for each microorganism. Selected distinguishers satisfy user specified bounds on length, melting temperature and GC content, as well as redundancy and cross-hybridization constraints.

Original languageEnglish (US)
Pages (from-to)3424-3426
Number of pages3
JournalBioinformatics
Volume21
Issue number16
DOIs
StatePublished - Aug 15 2005
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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