DNA damage response in cisplatin-induced nephrotoxicity

Shiyao Zhu, Navjotsingh Pabla, Chengyuan Tang, Liyu He, Zheng Dong

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.

Original languageEnglish (US)
Pages (from-to)2197-2205
Number of pages9
JournalArchives of Toxicology
Volume89
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • Apoptosis
  • Cisplatin
  • DNA damage
  • Kidney
  • Nephrotoxicity
  • P53

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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