Dobutamine stress echocardiography doppler estimation of cardiac diastolic function: A simultaneous catheterization correlation study

Albert K. Chan, Gurushankar Govindarajan, Marc L. Del Rosario, Kul Aggarwal, Kevin C. Dellsperger, Anand Chockalingam

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Doppler echocardiography using the ratio of early diastolic transmitral velocity to early diastolic mitral annular tissue velocity (E/E′) is routinely used to evaluate left ventricular (LV) filling pressures at rest. We tested the hypothesis that measurement of E/E′ in patients undergoing dobutamine stress echocardiography (DSE) will detect changes in LV filling pressures. Methods: In this prospective study, 16 patients with normal LV ejection fraction and normal coronary arteries by angiography underwent a standard DSE protocol with simultaneous LV filling pressure monitoring with a fluid filled pigtail catheter. Doppler echocardiographic assessment of LV diastolic function was performed using E/E′ at rest and during DSE. Results: The average age of the study participants was 57 ± 8 years. Average heart rate was 61 ± 11 bpm at baseline and 141 ± 12 bpm at peak stress. LV mean diastolic pressure decreased from 12.3 ± 2.6 mmHg at baseline to 9.0 ± 2.3 mmHg at peak stress (P = 0.0001). Baseline E/E′ at the septum and lateral annulus were 8.7 ± 2.2 and 7.5 ± 1.9 and during peak stress were 8.3 ± 3.1 and 7.9 ± 3.5, respectively. There was no significant change in E/E′ at either the septum or the lateral annulus (P = 0.55, P = 0.66). There was no significant correlation between LV mean diastolic pressure and E/E′ with dobutamine stress. Conclusions: In patients with normal LV ejection fraction and no significant coronary artery disease undergoing DSE, the ratio of early diastolic transmitral velocity to early diastolic tissue velocity (E/E′) at peak stress with dobutamine does not predict changes in LV filling pressures.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalEchocardiography
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Keywords

  • diastolic function
  • dobutamine stress echocardiography
  • left ventricular filling pressures
  • tissue Doppler echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Dobutamine stress echocardiography doppler estimation of cardiac diastolic function: A simultaneous catheterization correlation study'. Together they form a unique fingerprint.

  • Cite this

    Chan, A. K., Govindarajan, G., Del Rosario, M. L., Aggarwal, K., Dellsperger, K. C., & Chockalingam, A. (2011). Dobutamine stress echocardiography doppler estimation of cardiac diastolic function: A simultaneous catheterization correlation study. Echocardiography, 28(4), 442-447. https://doi.org/10.1111/j.1540-8175.2010.01360.x