Dobutamine stress echocardiography doppler estimation of cardiac diastolic function

A simultaneous catheterization correlation study

Albert K. Chan, Gurushankar Govindarajan, Marc L. Del Rosario, Kul Aggarwal, Kevin C. Dellsperger, Anand Chockalingam

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Doppler echocardiography using the ratio of early diastolic transmitral velocity to early diastolic mitral annular tissue velocity (E/E′) is routinely used to evaluate left ventricular (LV) filling pressures at rest. We tested the hypothesis that measurement of E/E′ in patients undergoing dobutamine stress echocardiography (DSE) will detect changes in LV filling pressures. Methods: In this prospective study, 16 patients with normal LV ejection fraction and normal coronary arteries by angiography underwent a standard DSE protocol with simultaneous LV filling pressure monitoring with a fluid filled pigtail catheter. Doppler echocardiographic assessment of LV diastolic function was performed using E/E′ at rest and during DSE. Results: The average age of the study participants was 57 ± 8 years. Average heart rate was 61 ± 11 bpm at baseline and 141 ± 12 bpm at peak stress. LV mean diastolic pressure decreased from 12.3 ± 2.6 mmHg at baseline to 9.0 ± 2.3 mmHg at peak stress (P = 0.0001). Baseline E/E′ at the septum and lateral annulus were 8.7 ± 2.2 and 7.5 ± 1.9 and during peak stress were 8.3 ± 3.1 and 7.9 ± 3.5, respectively. There was no significant change in E/E′ at either the septum or the lateral annulus (P = 0.55, P = 0.66). There was no significant correlation between LV mean diastolic pressure and E/E′ with dobutamine stress. Conclusions: In patients with normal LV ejection fraction and no significant coronary artery disease undergoing DSE, the ratio of early diastolic transmitral velocity to early diastolic tissue velocity (E/E′) at peak stress with dobutamine does not predict changes in LV filling pressures.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalEchocardiography
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Fingerprint

Stress Echocardiography
Ventricular Pressure
Catheterization
Dobutamine
Stroke Volume
Blood Pressure
Doppler Echocardiography
Coronary Angiography
Left Ventricular Function
Coronary Artery Disease
Coronary Vessels
Catheters
Heart Rate
Prospective Studies

Keywords

  • diastolic function
  • dobutamine stress echocardiography
  • left ventricular filling pressures
  • tissue Doppler echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Chan, A. K., Govindarajan, G., Del Rosario, M. L., Aggarwal, K., Dellsperger, K. C., & Chockalingam, A. (2011). Dobutamine stress echocardiography doppler estimation of cardiac diastolic function: A simultaneous catheterization correlation study. Echocardiography, 28(4), 442-447. https://doi.org/10.1111/j.1540-8175.2010.01360.x

Dobutamine stress echocardiography doppler estimation of cardiac diastolic function : A simultaneous catheterization correlation study. / Chan, Albert K.; Govindarajan, Gurushankar; Del Rosario, Marc L.; Aggarwal, Kul; Dellsperger, Kevin C.; Chockalingam, Anand.

In: Echocardiography, Vol. 28, No. 4, 01.04.2011, p. 442-447.

Research output: Contribution to journalArticle

Chan, AK, Govindarajan, G, Del Rosario, ML, Aggarwal, K, Dellsperger, KC & Chockalingam, A 2011, 'Dobutamine stress echocardiography doppler estimation of cardiac diastolic function: A simultaneous catheterization correlation study', Echocardiography, vol. 28, no. 4, pp. 442-447. https://doi.org/10.1111/j.1540-8175.2010.01360.x
Chan, Albert K. ; Govindarajan, Gurushankar ; Del Rosario, Marc L. ; Aggarwal, Kul ; Dellsperger, Kevin C. ; Chockalingam, Anand. / Dobutamine stress echocardiography doppler estimation of cardiac diastolic function : A simultaneous catheterization correlation study. In: Echocardiography. 2011 ; Vol. 28, No. 4. pp. 442-447.
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