Does increased leptin contribute to obesity hypertension?

E. W. Shek, H. L. Keen, J. R. Henegar, M. W. Brands, J. E. Hall

Research output: Contribution to journalArticle

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Abstract

Although plasma leptin concentration is markedly increased in hypertensive obese humans, the role of leptin in cardiovascular regulation is unclear. The aim of the present study was to determine if chronic elevation of plasma leptin, to levels that mimic those in obesity, alter renal function and increase blood pressure in normal Sprague-Dawley (SD) rats. Male SD rats (n=5) were implanted with arterial and venous catheters, and mean arterial pressure (MAP) and heart rate (HR) were monitored continuously, 24 hr/day. After 6 days of control measurements, a 5-day infusion of leptin (100 ng/kg/min, iv.) was started. Daily sodium intake was maintained constant at 2.8 mEq/day. Leptin infusion for 5 days did not significantly alter any variables that were measured. MAP HR Food UV UNaV GFR (mmHg) (beats/min) (g/day) (ml/day) (mEq/day) (ml/min) Control 94±2 349±11 16±1 31±7 2.6±0.2 2.7±0.1 Leptin 95±2 34&11 16±1 32±6 2.5±0.2 2.8±0.1 [UV: urinary volume; UNaV: urinary sodium excretion; GFR: glomerular filtration rate] These observations suggest that chronic elevation of plasma leptin, to values observed in obesity, have minimal effects on cardiovascular and renal function.

Original languageEnglish (US)
Pages (from-to)A258
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

Fingerprint

Leptin
Obesity
Hypertension
Plasmas
Sprague Dawley Rats
Rats
Arterial Pressure
Heart Rate
Sodium
Kidney
Catheters
Blood pressure
Glomerular Filtration Rate
Blood Pressure
Food

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Shek, E. W., Keen, H. L., Henegar, J. R., Brands, M. W., & Hall, J. E. (1997). Does increased leptin contribute to obesity hypertension? FASEB Journal, 11(3), A258.

Does increased leptin contribute to obesity hypertension? / Shek, E. W.; Keen, H. L.; Henegar, J. R.; Brands, M. W.; Hall, J. E.

In: FASEB Journal, Vol. 11, No. 3, 01.12.1997, p. A258.

Research output: Contribution to journalArticle

Shek, EW, Keen, HL, Henegar, JR, Brands, MW & Hall, JE 1997, 'Does increased leptin contribute to obesity hypertension?', FASEB Journal, vol. 11, no. 3, pp. A258.
Shek EW, Keen HL, Henegar JR, Brands MW, Hall JE. Does increased leptin contribute to obesity hypertension? FASEB Journal. 1997 Dec 1;11(3):A258.
Shek, E. W. ; Keen, H. L. ; Henegar, J. R. ; Brands, M. W. ; Hall, J. E. / Does increased leptin contribute to obesity hypertension?. In: FASEB Journal. 1997 ; Vol. 11, No. 3. pp. A258.
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