Does left atrial volume affect exercise capacity of heart transplant recipients?

Mohammad Abdul-Waheed, Mian Yousuf, Stephanie J. Kelly, Ross Arena, Jun Ying, Tehmina Naz, Stephanie Hope Dunlap, Yukitaka Shizukuda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Heart transplant (HT) recipients demonstrate limited exercise capacity compared to normal patients, very likely for multiple reasons. In this study we hypothesized that left atrial volume (LAV), which is known to predict exercise capacity in patients with various cardiac pathologies including heart failure and hypertrophic cardiomyopathy is associated with limited exercise capacity of HT recipients.Methods: We analyzed 50 patients [age 57 ±2 (SEM), 12 females] who had a post-HT echocardiography and cardiopulmonary exercise test (CPX) within 9 weeks time at clinic follow up. The change in LAV (ΔLAV) was also computed as the difference in LAV from the preceding one-year to the study echocardiogram. Correlations among the measured parameters were assessed with a Pearson's correlation analysis.Results: LAV (n = 50) and ΔLAV (n = 40) indexed to body surface area were 40.6 ± 11.5 ml·m -2 and 1.9 ± 8.5 ml·m -2· year -1 , data are mean ± SD, respectively. Indexed LAV and ΔLAV were both significantly correlated with the ventilatory efficiency, assessed by the VE/VCO 2 slope (r = 0.300, p = 0.038; r = 0.484, p = 0.002, respectively). LAV showed a significant correlation with peak oxygen consumption (r = -0.328, p = 0.020).Conclusions: Although our study is limited by a retrospective study design and relatively small number of patients, our findings suggest that enlarged LAV and increasing change in LAV is associated with the diminished exercise capacity in HT recipients and warrants further investigation to better elucidate this relationship.

Original languageEnglish (US)
Article number113
JournalJournal of Cardiothoracic Surgery
Volume5
Issue number1
DOIs
StatePublished - Nov 17 2010

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Exercise
Body Surface Area
Hypertrophic Cardiomyopathy
Exercise Test
Oxygen Consumption
Echocardiography
Heart Failure
Retrospective Studies
Pathology
Transplants
Transplant Recipients

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Abdul-Waheed, M., Yousuf, M., Kelly, S. J., Arena, R., Ying, J., Naz, T., ... Shizukuda, Y. (2010). Does left atrial volume affect exercise capacity of heart transplant recipients? Journal of Cardiothoracic Surgery, 5(1), [113]. https://doi.org/10.1186/1749-8090-5-113

Does left atrial volume affect exercise capacity of heart transplant recipients? / Abdul-Waheed, Mohammad; Yousuf, Mian; Kelly, Stephanie J.; Arena, Ross; Ying, Jun; Naz, Tehmina; Dunlap, Stephanie Hope; Shizukuda, Yukitaka.

In: Journal of Cardiothoracic Surgery, Vol. 5, No. 1, 113, 17.11.2010.

Research output: Contribution to journalArticle

Abdul-Waheed, M, Yousuf, M, Kelly, SJ, Arena, R, Ying, J, Naz, T, Dunlap, SH & Shizukuda, Y 2010, 'Does left atrial volume affect exercise capacity of heart transplant recipients?', Journal of Cardiothoracic Surgery, vol. 5, no. 1, 113. https://doi.org/10.1186/1749-8090-5-113
Abdul-Waheed, Mohammad ; Yousuf, Mian ; Kelly, Stephanie J. ; Arena, Ross ; Ying, Jun ; Naz, Tehmina ; Dunlap, Stephanie Hope ; Shizukuda, Yukitaka. / Does left atrial volume affect exercise capacity of heart transplant recipients?. In: Journal of Cardiothoracic Surgery. 2010 ; Vol. 5, No. 1.
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AB - Background: Heart transplant (HT) recipients demonstrate limited exercise capacity compared to normal patients, very likely for multiple reasons. In this study we hypothesized that left atrial volume (LAV), which is known to predict exercise capacity in patients with various cardiac pathologies including heart failure and hypertrophic cardiomyopathy is associated with limited exercise capacity of HT recipients.Methods: We analyzed 50 patients [age 57 ±2 (SEM), 12 females] who had a post-HT echocardiography and cardiopulmonary exercise test (CPX) within 9 weeks time at clinic follow up. The change in LAV (ΔLAV) was also computed as the difference in LAV from the preceding one-year to the study echocardiogram. Correlations among the measured parameters were assessed with a Pearson's correlation analysis.Results: LAV (n = 50) and ΔLAV (n = 40) indexed to body surface area were 40.6 ± 11.5 ml·m -2 and 1.9 ± 8.5 ml·m -2· year -1 , data are mean ± SD, respectively. Indexed LAV and ΔLAV were both significantly correlated with the ventilatory efficiency, assessed by the VE/VCO 2 slope (r = 0.300, p = 0.038; r = 0.484, p = 0.002, respectively). LAV showed a significant correlation with peak oxygen consumption (r = -0.328, p = 0.020).Conclusions: Although our study is limited by a retrospective study design and relatively small number of patients, our findings suggest that enlarged LAV and increasing change in LAV is associated with the diminished exercise capacity in HT recipients and warrants further investigation to better elucidate this relationship.

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