Abstract
Imatinib (IM)-associated myelosuppression is rare in gastrointestinal stromal cell tumors (<10%) but common in chronic myeloid leukemia (CML). Selective inhibition of predominantly Philadelphia chromosome (Ph+) driven hematopoiesis may explain myelosuppression in CML. In the absence of clinical methods to quantitate the Ph+/Ph- progenitor ratio, we hypothesized that the pre-IM percentage of BCR-ABL+ cells measured by fluorescence in situ hybridization (FISH) predicts for myelosuppression. FISH analyses performed within 30 days pre-IM 400 mg/day were analyzed in 89 patients with chronic phase CML at three institutions. Patients who developed grade ≥3 cytopenias had a higher percentage of positive FISH (90% vs. 83%; p = 0.02). Cytopenias lasted a median of 16 days, and all patients but one continued IM, achieved complete hematologic and cytogenetic remissions, and did not experience progression, with a follow-up of 61 months. In conclusion, IM-associated cytopenias are associated with a high pre-IM FISH, are reversible, and do not adversely affect outcomes.
Original language | English (US) |
---|---|
Pages (from-to) | 1010-1016 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 52 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2011 |
Externally published | Yes |
Keywords
- CML
- Myelosuppression
- imatinib
- outcomes
- risk
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research