Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats

U. Frey, S. Hartmann, H. Matthies

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Abstract

The influence of the D2-receptorblocker domperidone (DP) at a concentration of 1 μM was investigated on an electrically induced long-term potentiation (LTP) measured as the enhancement of the population spike (PS) amplitude in the hippocampal CA1. It could be shown that the drug does not influence the initiation but the maintenance of LTP. The results once again support the hypothesis that different phases of LTP exist which are realized by different cellular inputs.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalBiomedica Biochimica Acta
Volume48
Issue number7
StatePublished - Jan 1 1989

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Domperidone
Long-Term Potentiation
Rats
Pharmaceutical Preparations
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ASJC Scopus subject areas

  • Biochemistry

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Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats. / Frey, U.; Hartmann, S.; Matthies, H.

In: Biomedica Biochimica Acta, Vol. 48, No. 7, 01.01.1989, p. 473-476.

Research output: Contribution to journalArticle

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