Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys

Jerry J. Buccafusco, Alvin V. Terry

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Donepezil (Aricept®), a long-acting cholinesterase inhibitor, is widely used in the treatment of Alzheimer's disease to improve cognition and memory. Many drugs within the class of cognition-enhancing agents, both currently approved medications and those under development, have clinical indications narrowly relegated to Alzheimer's disease. The purpose of this study was to determine whether the efficacy attributed to donepezil in its ability to improve delayed matching accuracy by monkeys was independent of age. Male and female rhesus monkeys (n = 17) ranging from 9 to 29 yr of age were administered donepezil (10, 25, 50, and 100 μg/kg, im) during 4 discrete test days. Donepezil treatment improved average task accuracy, but intersubject variability prohibited statistical significance. When animals were considered individually, the most effective dose of donepezil was associated with a highly significant increase in group task performance that was consistent with enhanced recall during testing. The variability associated with the dose-response analysis was attributable primarily to subject age, such that older monkeys required higher doses of donepezil. Yet at doses that were effective in all subjects, there was no relationship between age and the improvement in task accuracy. Likewise, there was no association between baseline task proficiency and improvement in task accuracy.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalJournal of Molecular Neuroscience
Volume24
Issue number1
DOIs
StatePublished - Aug 2004

Keywords

  • Aging
  • Cholinesterase inhibitor
  • Cognition
  • Delayed matching
  • Donepezil
  • Memory
  • Nonhuman primate
  • Recall

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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