Abstract
Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-125 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 119 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Dec 10 1985 |
| Externally published | Yes |
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Keywords
- D receptors
- SKF 38393
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393. / Cunningham, Kathryn A.; Callahan, Patrick Michael; Appel, James B.
In: European Journal of Pharmacology, Vol. 119, No. 1-2, 10.12.1985, p. 121-125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393
AU - Cunningham, Kathryn A.
AU - Callahan, Patrick Michael
AU - Appel, James B.
PY - 1985/12/10
Y1 - 1985/12/10
N2 - Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.
AB - Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.
KW - D receptors
KW - SKF 38393
UR - http://www.scopus.com/inward/record.url?scp=0022273549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022273549&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(85)90330-9
DO - 10.1016/0014-2999(85)90330-9
M3 - Article
VL - 119
SP - 121
EP - 125
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -