Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393

Kathryn A. Cunningham; Patrick M. Callahan; James B. Appel

doi:10.1016/0014-2999(85)90330-9

Dopamine D₁ receptor mediation of the discriminative stimulus properties of SKF 38393

Kathryn A. Cunningham, Patrick M. Callahan, James B. Appel

Research output: Contribution to journal › Article

32 Scopus citations

Abstract

Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D₁ and D₂ receptor agonists and antagonists. The D₂ agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D₁ antagonist Sch 23390, but not the D₂ antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D₁ receptors.

Original language	English (US)
Pages (from-to)	121-125
Number of pages	5
Journal	European Journal of Pharmacology
Volume	119
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(85)90330-9
State	Published - Dec 10 1985
Externally published	Yes

Keywords

D receptors
SKF 38393

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(85)90330-9

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Cunningham, K. A., Callahan, P. M., & Appel, J. B. (1985). Dopamine D₁ receptor mediation of the discriminative stimulus properties of SKF 38393. European Journal of Pharmacology, 119(1-2), 121-125. https://doi.org/10.1016/0014-2999(85)90330-9

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