TY - JOUR
T1 - Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393
AU - Cunningham, Kathryn A.
AU - Callahan, Patrick M.
AU - Appel, James B.
N1 - Funding Information:
This research was supported by USPHS Research Grant 2 RO1 DA 02543 from the National Institute on Drug Abuse. We wish to thank the following companies for their generous gifts of drugs: Eli Lilly and Co., Indianapolis, IN (Ly 171555): Schering Corp., Bloomfield, NJ (Sch 23390); Smith Kline and French, West Point, PA (SKF 38393). We also thank Stanley Davis for assistance with data analysis and Sue Hilfer and the staff of Medical Illustrations (USC Medical School) for graphics and photography assistance.
PY - 1985/12/10
Y1 - 1985/12/10
N2 - Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.
AB - Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.
KW - D receptors
KW - SKF 38393
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U2 - 10.1016/0014-2999(85)90330-9
DO - 10.1016/0014-2999(85)90330-9
M3 - Article
C2 - 2935415
AN - SCOPUS:0022273549
VL - 119
SP - 121
EP - 125
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -