Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393

Kathryn A. Cunningham; Patrick M. Callahan; James B. Appel

doi:10.1016/0014-2999(85)90330-9

Dopamine D₁ receptor mediation of the discriminative stimulus properties of SKF 38393

Kathryn A. Cunningham, Patrick M. Callahan, James B. Appel

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D₁ and D₂ receptor agonists and antagonists. The D₂ agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D₁ antagonist Sch 23390, but not the D₂ antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D₁ receptors.

Original language	English (US)
Pages (from-to)	121-125
Number of pages	5
Journal	European Journal of Pharmacology
Volume	119
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(85)90330-9
State	Published - Dec 10 1985
Externally published	Yes

Keywords

D receptors
SKF 38393

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(85)90330-9

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title = "Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393",

abstract = "Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.",

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AU - Callahan, Patrick M.

AU - Appel, James B.

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