Dopamine receptor-interacting proteins: The Ca2+ connection in dopamine signaling

Clare M Bergson, Robert Levenson, Patricia S. Goldman-Rakic, Michael S. Lidow

Research output: Contribution to journalReview article

140 Citations (Scopus)

Abstract

Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca2+ sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca2+ homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.

Original languageEnglish (US)
Pages (from-to)486-492
Number of pages7
JournalTrends in Pharmacological Sciences
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2003

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Receptor-Interacting Protein Serine-Threonine Kinases
Dopamine Receptors
Dopamine
Plakins
Dopamine Agents
Aptitude
Psychiatry
Schizophrenia
Homeostasis
Brain
Safety
Proteins
Defects
Sensors
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Dopamine receptor-interacting proteins : The Ca2+ connection in dopamine signaling. / Bergson, Clare M; Levenson, Robert; Goldman-Rakic, Patricia S.; Lidow, Michael S.

In: Trends in Pharmacological Sciences, Vol. 24, No. 9, 01.09.2003, p. 486-492.

Research output: Contribution to journalReview article

Bergson, Clare M ; Levenson, Robert ; Goldman-Rakic, Patricia S. ; Lidow, Michael S. / Dopamine receptor-interacting proteins : The Ca2+ connection in dopamine signaling. In: Trends in Pharmacological Sciences. 2003 ; Vol. 24, No. 9. pp. 486-492.
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