Dose adjustment of carboplatin in patients on peritoneal dialysis

Achuta Kumar Guddati, Parijat S. Joy, Creticus P. Marak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The Calvert equation has been extensively used to determine the dosage of carboplatin. However, in patients on dialysis, it predicts the same dosage regardless of the frequency of dialysis. Clearance of carboplatin during hemodialysis has been studied to a lesser extent, but there have been very few studies which have investigated the clearance of carboplatin in patients on peritoneal dialysis. A mathematical formula is proposed here to predict the dose of carboplatin for a given AUC in patients on peritoneal dialysis. This formula takes into account the frequency of dialysis sessions and the time delay between carboplatin infusion and the initiation of dialysis. The formula predicts an approximately similar dosage of carboplatin as that of the Calvert formula in patients undergoing peritoneal dialysis four times per day if dialysis is initiated 12 h after infusion. The formula may help in guiding the adjustment of carboplatin dose in patients who receive a lesser number of dialysis sessions per day and in those patients whose dialysis is initiated at different times (0-24 h) after carboplatin infusion. It is suggested that usage of this formula will result in a better dosage of carboplatin to suit specific dialysis frequencies in specific patients and eventually may result in a better efficacy and toxicity profile.

Original languageEnglish (US)
JournalMedical Oncology
Volume31
Issue number5
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Carboplatin
Peritoneal Dialysis
Dialysis
Area Under Curve
Renal Dialysis

Keywords

  • AUC
  • Carboplatin
  • Dose
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Dose adjustment of carboplatin in patients on peritoneal dialysis. / Guddati, Achuta Kumar; Joy, Parijat S.; Marak, Creticus P.

In: Medical Oncology, Vol. 31, No. 5, 01.01.2014.

Research output: Contribution to journalArticle

Guddati, Achuta Kumar ; Joy, Parijat S. ; Marak, Creticus P. / Dose adjustment of carboplatin in patients on peritoneal dialysis. In: Medical Oncology. 2014 ; Vol. 31, No. 5.
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