Dose of Fluphenazine, Familial Expressed Emotion, and Outcome in Schizophrenia

Results of a Two-Year Controlled Study

Gerard E. Hogarty, Joseph Patrick McEvoy, Mark Munetz, Ann Louise Dibarry, Patricia Bartone, Rosemary Cather, Susan J. Cooley, Richard F. Ulrich, Mary Carter, Michael J. Madonia

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

• Issues regarding the side effects of antipsychotic medication and the possible contribution of the environment to dose requirements led to a two-year controlled dosage study of maintenance antipsychotic medication and familial environment among recently discharged schizophrenic patients. Seventy stable patients, living in high— or low—expressed emotion (EE) households, were randomized, double blind, to receive a standard dose of fluphenazine decanoate (average, 25 mg every two weeks) or a minimal dose representing 20% of the dose prescribed (average, 3.8 mg every two weeks). No differences in relapse were observed among dose, EE, or dose and EE. Patients in the minimal dose/high-EE condition experienced more minor but aborted episodes in year 2. Side effects were fewer on the minimal dose after one year, and low-EE patients were better adjusted than high-EE patients. Over time, minimal-dose recipients were significantly more improved in their instrumental and interpersonal role performance than were standard-dose recipients.

Original languageEnglish (US)
Pages (from-to)797-805
Number of pages9
JournalArchives of General Psychiatry
Volume45
Issue number9
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Expressed Emotion
Fluphenazine
Schizophrenia
Antipsychotic Agents
Emotions
Maintenance
Controlled
Emotion
Familial
Dose
Recurrence

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Dose of Fluphenazine, Familial Expressed Emotion, and Outcome in Schizophrenia : Results of a Two-Year Controlled Study. / Hogarty, Gerard E.; McEvoy, Joseph Patrick; Munetz, Mark; Dibarry, Ann Louise; Bartone, Patricia; Cather, Rosemary; Cooley, Susan J.; Ulrich, Richard F.; Carter, Mary; Madonia, Michael J.

In: Archives of General Psychiatry, Vol. 45, No. 9, 01.01.1988, p. 797-805.

Research output: Contribution to journalArticle

Hogarty, GE, McEvoy, JP, Munetz, M, Dibarry, AL, Bartone, P, Cather, R, Cooley, SJ, Ulrich, RF, Carter, M & Madonia, MJ 1988, 'Dose of Fluphenazine, Familial Expressed Emotion, and Outcome in Schizophrenia: Results of a Two-Year Controlled Study', Archives of General Psychiatry, vol. 45, no. 9, pp. 797-805. https://doi.org/10.1001/archpsyc.1988.01800330021002
Hogarty, Gerard E. ; McEvoy, Joseph Patrick ; Munetz, Mark ; Dibarry, Ann Louise ; Bartone, Patricia ; Cather, Rosemary ; Cooley, Susan J. ; Ulrich, Richard F. ; Carter, Mary ; Madonia, Michael J. / Dose of Fluphenazine, Familial Expressed Emotion, and Outcome in Schizophrenia : Results of a Two-Year Controlled Study. In: Archives of General Psychiatry. 1988 ; Vol. 45, No. 9. pp. 797-805.
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